Videos


Cholangiocarcinoma Foundation Videos

Webinar: Role of CEACAM6 as a Biomarker in Cholangiocarcinoma

Presenter:   Flavio Rocha, MD Title of Presentation:   Targeting BAP1 Mutations in Intrahepatic Cholangiocarcinoma Summary of Presentation:   There are no good biomarkers for the early diagnosis of cholangiocarcinoma. CEACAM6 is an extracellular protein involved in cell signaling.  When overexpressed in gastrointestinal malignancies such as pancreas and colon cancer, it is associated with worse prognosis.  Therefore we hypothesized that if CEACAM6 can be detected in the bile of patients of cholangiocarcinoma, it may serve as an early marker of disease.  Bile was collected from patients undergoing resection for cholangiocarcinoma and from patients with benign biliary disease.  Biliary CEACAM6 levels were determined by enzyme-linked immunosorbent assay and Western blot.  Higher CEACAM6levels were found in the bile of patients with bile duct cancer especially extrahepatic cholangiocarcinoma. Future studies with a larger...

Webinars: Targeting BAP1 Mutations & Development of a Mouse Model

Presenter:   Milind Javle, MD Title of Presentation:   Targeting BAP1 Mutations in Intrahepatic Cholangiocarcinoma Summary of Presentation: The purpose of this study is to identify molecular subgroups of cholangiocarcinoma by estimating the frequency of BAP1 mutations in patients with intrahepatic cholangiocarcinoma, examining BAP1 and other genes in cholangiocarcinoma to link with diagnosis and patient outcomes, and developing a mouse model of BAP1 that can be used for clinical studies of new drugs. >>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>  Presenter:   Rebecca Marcus, MD Title of Presentation:   Of mice and men – Development of a Mouse Model for intrahepatic Cholangiocarcinoma Summary of Presentation: Cholangiocarcinoma is a lethal bile duct malignancy, and the second most common primary hepatic malignancy.  A subtype of this disease,intrahepatic cholangiocarcinoma (ICC), is increasing worldwide, and characterized by a...

CCF Grantee Webinar Series II

Determining the Cellular Origins of Cholangiocarcinoma Allyson Merrell, University of Pennsylvania (Powerpoint Slides) A Balancing Act: Dysregulated Differentiation and Proliferation as a Novel Mechanism of Cholangiocarcinoma Formation Chad Walesky, Brigham and Women’s Hospital (Powerpoint Slides)...

CCF Grantee Webinar Series I

Part 1 Implementation of Precision Medicine Approaches in Intrahepatic Cholangiocarcinoma Daniela Sia, Icahn School of Medicine at Mount Sinai (Powerpoint Slides) Part 2 Fibroblast Growth Factor Receptor FGFR Family Gene Aberrations in Cholangiocarcinoma Katsuyuki Miyabe, Mayo Clinic (Powerpoint...

What Patients Need to Know About Hilar Cholangiocarcinoma and Liver Transplant

On Tuesday, Aug. 11 at Noon CT, Mayo Clinic hosted an interactive webinar on hilar cholangiocarcinoma (cancer of the bile ducts). Julie Heimbach, MD, Liver Transplant Program Surgical Director, and Sumera Rizvi, MBBS, Gastroenterology and Hematology Fellow, discussed hilar cholangiocarcinoma symptoms, diagnosis, and treatment options, including liver transplantation. A live question and answer session followed the...

Recent Advances in Adjuvant Therapy for Cholangiocarcinoma

Description: Filmed on location in New York during the Great Debates and Updates in GI Malignancies 2015, this webcast is part of a series that provides educational discussions on controversial areas in the management of gastrointestinal malignancies. Join us as nationally-recognized thought leaders take opposing sides on topics of clinical interest, and present updates in standards of care. In this presentation, Dr. Abby Siegel discusses the most recent advances in adjuvant therapy for cholangiocarcinoma. Courtesy of:...

Webinar: Using “Spacers” for Safer Delivery of High Dose Radiation Therapy

Webinar: Using “Spacers” for Safer Delivery of High Dose Radiation Therapy High dose radiation therapy is effective in the treatment of liver tumors. However, the greatest limitation in the use of radiation is not the liver itself, but rather adjacent organs like the stomach or intestines, which do not tolerate high doses of radiation therapy. The use of laparoscopically-placed spacers can safely provide critical distance between a liver tumor and these sensitive organs and allow for therapeutic treatment of liver tumors, expanding the number of patients who can be offered potentially curative high dose radiation therapy. Download the Slides Dr. Theodore Hong Director of Gastrointestinal Radiation Oncology at Massachusetts General Hospital and Associate Professor of Radiation Oncology at Harvard Medical School Dr. Theodore Hong...

Webinar: The Emerging Role of Radiation for Intrahepatic Cholangiocarcinoma: Higher Doses Lead to Improved Survival

This presentation focused on the non-operative treatment of intrahepatic cholangiocarcinoma. Over the past 5 years, new technology has allowed much higher doses of radiation to be given safely. These doses are capable of ablating the tumor and preventing it from causing liver failure and death, leading to much longer survival and a realistic chance for cure. Results from MD Anderson demonstrate outcomes comparable to surgical resection.  Download the Slides Professor Christopher Crane, MD Program Director and Chief of the Gastrointestinal Section, Department of Radiation Oncology at the University of Texas M. D. Anderson Cancer Center Professor Christopher Crane, MD, is Program Director and Chief of the Gastrointestinal Section, in the Department of Radiation Oncology at the University of Texas M. D. Anderson Cancer...

Webinar: Photodynamic Therapy, A Ray of Light in Cholangiocarcinoma: The OPUS Trial

“Photodynamic Therapy, A Ray of Light in Cholangiocarcinoma: The OPUS Trial” presented by Dr. David E. Loren, Associate Director of Endoscopy and Co-Director of the Pancreaticobiliary Section at Thomas Jefferson University Hospital. Cholangiocarcinoma is a disease that often leaves patients and their physicians feeling that they have few options for treatment. This presentation discusses an emerging treatment option for patients whose cholangiocarcinoma is not able to be removed by surgery. Dr. David Loren Associate Director of Endoscopy and Co-Director of the Pancreaticobiliary Section, Thomas Jefferson University Hospital Dr. David E. Loren is the Associate Director of Endoscopy and Co-Director of the Pancreaticobiliary Section at Thomas Jefferson University Hospital. He has extensive experience treating patients with cholangiocarcinoma and cares for one of the largest cohorts of patients with cholangiocarcinoma...

Surgical Management of Cholangiocarcinoma – State of the Art and Beyond

Title: Surgical Management of Cholangiocarcinoma – State of the Art and Beyond When:Thursday, Nov 13, 2014,  3:00 PM – 4:00 PM EST Presented by: Dr. Tomoaki Kato, Chief of the Division of Abdominal Organ Transplantation at New York-Presbyterian Hospital/Columbia University Medical Center Description: This webinar will feature Dr. Tomoaki Kato, a renowned expert in liver and intestinal transplantation and complex abdominal and hepatobiliary surgeries. Since 2008, Dr. Kato has served as Chief of the Division of Abdominal Organ Transplantation at New York-Presbyterian Hospital/Columbia University Medical Center. He has been leading the institution’s liver transplant program, using both deceased and living donor livers. This session will focus on current techniques being used for surgical management of cholangiocarcinoma and the promise of potential treatments for patients in the future....

Using Patients’ Own Immune System to Knock-out Cancer: Adoptive Cell Therapy

Click here to download the presentation (.pdf)   Topic:  Using Patients’ Own Immune System to Knock-out Cancer: Adoptive Cell Therapy Presenters: Steven A. Rosenberg, M.D., Ph.D., National Cancer Institute Eric Tran, Ph.D., National Institutes of Health Surgery Branch, Tumor Immunology Section Melinda Bachini, CCF Patient Advocate and NIH Research Study Participant Overview: Join Dr. Steven A. Rosenberg (National Cancer Institute) and Dr. Eric Tran (National Institutes of Health) in a webinar about NIH clinical trial NCT01174121 using adoptive cell therapy, a technique that harnesses a person’s own immune system to battle cancer. Dr. Rosenberg, M.D., Ph.D, a pioneer in the development of adoptive cell therapy, will discuss the background, objectives and frequently asked questions about this clinical trial. Dr. Tran, Ph.D., will explain how scientists at the NIH were able to grow billions of immune...

Video: My Toughest Marathon-A Runner’s Perspective on Cancer

On September 29, CCF held its first web chat with guest speaker Bill Merriam. Bill recently created a new video for the Foundation to share his perspective on cancer. Participants were able to submit questions in advance and join the web chat to hear directly from Bill. Bill is the father of 6 and grandfather of 13.  He was diagnosed with cholangiocarcinoma in 2009.   In this inspirational video and webchat, he shares his “story” and perspective on cancer from a marathon runner’s point-of-view: “I have cancer but I am not going to let it stop me from being an active participant in the most active way that can as a father, spouse, and as a family-head so it becomes the new normal . . ....

Webinar: Palliative Surgery for Patients with Cholangiocarcinoma

Some people with cholangiocarcinoma are unable to be cured because their tumor is either inoperable or has spread. These patients can develop blockages of the bile ducts or intestines causing jaundice, severe itching, nausea and/or vomiting. Palliative surgery or endoscopic procedures may be able to provide relief of symptoms. We will be discussing the role of biliary bypass and stenting for bile duct blockages as well the role of surgery and stenting for intestinal blockages. Dr. Scott Celinski is a surgical oncologist who specializes in treating complex cancers of the liver and pancreas. He currently serves as the Director of the Pancreatic Cancer Research and Treatment Center at Baylor University Medical Center in Dallas, TX. His earned his medical degree from Baylor College of...

Webinar: Update on Cholangiocarcinoma – What we have learned from the International Hepatobiliary Neoplasia Biorepository

Topic:    “Update on Cholangiocarcinoma: What we have learned from the International Hepatobiliary Neoplasia Biorepository” Presenter: Dr. Roongruedee Chaiteerakij, Mayo Clinic, MN Purpose: Educate patients so they better understand how Mayo Clinic is using the information and bio-specimens they provide to improve care all for cholangiocarcinoma patients.   Download the Powerpoint Presentation...

Modeling Cholangiocarcinoma

Modeling Cholangiocarcinoma Webinar from Cholangiocarcinoma Foundation on Vimeo. “Like all cancers, cholangiocarcinoma is a genetic disease.  I will present our effort to comprehensively characterize the genetic landscape of cholangiocarcinoma and to use this information to develop genetically representative models of this disease that will serve as instrumental tools in our search for novel therapies. ”  –...

Understanding Cancer in the Age of Genomics

Understanding Cancer in the Age of Genomics from Cholangiocarcinoma Foundation on Vimeo. Presented by Dr. C. Jimmy Lin MD, PhD, MHS. About Dr. Lin and his work in...

New Intrahepatic Cholangiocarcinoma Clinical Trial

New Intrahepatic Cholangiocarcinoma Clinical Trial from Cholangiocarcinoma Foundation on Vimeo. Intrahepatic cholangiocarcinoma affect approximately 2000 people a year in the US. Many patients are not able to have an operation to remove the bile duct cancer. We are preparing to enroll patients in a clinical trial which includes patients who can have an operation and those who...

Feeling Guilty for Having Cancer

Feeling Guilty for Having Cancer from Cholangiocarcinoma Foundation on Vimeo. No one asks for cancer, but when the diagnosis is confirmed some patients feel guilty for being sick! In this informative webinar, Dr. Geret Giles discusses the phenomena of Patient Guilt and what we can do about it–for ourselves and for the ones we...

Grant Recipient Reports on Research Progress

Grant Recipient Reports on Research Progress from Cholangiocarcinoma Foundation on Vimeo. Surbpong Tanasanvimon received a LIFe recipient grant from The Cholangiocarcinoma Foundation in 2012 this grant was awarded through the Conquer Cancer Foundation (which is the non-profit arm of ASCO). He recently had the opportunity to present his research at the 2013 GI...

Patient Registry

Dr. Lewis Roberts from The Mayo Clinical will highlight details about the patient registry at The Mayo Clinic, and how this registry can assist with efforts in advancing research of bile duct...

Biliary Tract Diseases

The Cholangiocarcinoma Foundation, in partnership with the Primary Schlerosing Cholangitis Foundation, hosted this webinar focused on...