The Cholangiocarcinoma Foundation awarded $184,202 in Grants and Project Funding in 2012. A $40,000 Grant was awarded to the UCSF Hepatobiliary Tissue Bank(CC#124512) which will support the advancing translational Science in Cancers of Biliary Tract through Biorepository of Human Tumor and Blood Specimens. The goal of the HBTB is to advance our understanding of this rare and under-studied tumor type. The immediate goal of the HBTB is to collect high quality frozen cholangiocarcinoma specimens along with paired normal tissue (blood or normal liver) to support the opening of a cholangiocarcinoma cohort with the National Cancer Institute’s the Cancer Genome Atlas (TCGA). Another $40,000 was awarded for Cell Lines and Novel Antibodies at Massachusetts General Hospital. The support will test a novel immunotherapeutic strategy which targets not only differentiated cholangiocarcinoma cells, but all cholangiocarcinoma stem cells. An additional $44,202 was given to the Mayo Clinic for Hepatobiliary Neoplasia Registry and Biorepository. The overall goal is to support the collection of clinical information and samples of blood and tissue from patients with hepatobiliary neoplasia in an IRB approved International Hepatobiliary Neoplasia Registry and Biorepository. Finally, The American Society of Clinical Oncology was awarded $60,000 for its Young Investigator Award. This grant is intended to raise awareness and trigger progress against cholangiocarcinoma, while providing critical early funding for physician-scientists at the beginning of their careers in the field. Providing early career grants helps encourage investigators to focus their career on bile duct cancer.