Order of treatment

Discussion Board Forums Chemotherapy & More Order of treatment

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  • #84904
    marions
    Moderator

    Duke….this is what I have learned. Chemo attacks the cells at a particular stage.

    The cell cycle is important because many chemotherapy drugs work only on cells that are
    actively reproducing (not cells that are in the resting phase, G0). Some drugs specifically
    attack cells in a particular phase of the cell cycle (the M or S phases, for example).
    Understanding how these drugs work helps oncologists predict which drugs are likely to
    work well together. Doctors can also plan how often doses of each drug should be given
    based on the timing of the cell phases.
    Chemotherapy drugs cannot tell the difference between reproducing cells of normal
    tissues (those that are replacing worn-out normal cells) and cancer cells. This means
    normal cells are damaged and this results in side effects. Each time chemotherapy is
    given, it involves trying to find a balance between destroying the cancer cells (in order to
    cure or control the disease) and sparing the normal cells (to lessen unwanted side effects).

    The Cell Cycle
    G0 phase (resting stage): The cell has not yet started to divide. Cells spend much
    of their lives in this phase. Depending on the type of cell, G0 can last from a few
    hours to a few years. When the cell gets a signal to reproduce, it moves into the
    G1 phase.
    G1 phase: During this phase, the cell starts making more proteins and growing
    larger, so the new cells will be of normal size. This phase lasts about 18 to 30
    hours.
    S phase: In the S phase, the chromosomes containing the genetic code (DNA) are
    copied so that both of the new cells formed will have matching strands of DNA.
    The S phase lasts about 18 to 20 hours.
    G2 phase: In the G2 phase, the cell checks the DNA and gets ready to start
    splitting into 2 cells. This phase lasts from 2 to 10 hours.
    M phase (mitosis): In this phase, which lasts only 30 to 60 minutes, the cell actually splits into 2 new cells.
    Source: cancer/org

    #10593
    dukenukem
    Member

    I’m back on carboplatin and gemcitabine for now. The carbo effects seem to last about 10 days. So, why is it done on day 1 instead of day 8? Administering it on day 8 would give it 14 days to get out of the system before the next round. Should help the body recover more before the gem treatment.

    Duke

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