I am currently receiving my first Gem/Cs regimen, half way through now. I haven’t had much problem from the drugs themselves yet, other than a day or two of mild flu-like symptoms and fatigue. A very low-grade nausea is well controlled with Zofran. My biggest problem so far related to the treatment has been that the Zofran resulted in severe constipation, so I have been working on a combination of fiber, diet, stool softeners, etc. that will keep my digestive system in balance. Interestingly, the final addition that seemed to really do the trick was eating a couple of diet chocolates every evening for dessert. Russell Stover chocolates, in addition to being very good, are sweetened with one or more sugar alcohols (look for sorbitol or maltitol on the ingredients list), which have a significant laxative effect for many people. So, a nice solution, overall!