Statins induce apoptosis and inhibit proliferation in cholangiocarcino

Discussion Board Forums New Developments Statins induce apoptosis and inhibit proliferation in cholangiocarcino

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  • #51204
    marions
    Moderator

    Thanks Percy, for your generosity and kindness in offering the help needed to understand research studies better.
    All my best,
    Marion

    #51203
    pcl1029
    Member

    Hi,Marion,
    Thanks for this info.,I will never have enough time to search everything and read everything;that is why everybody’s help is vital .Thanks again.
    Our livers produce cholesterol and cholesterol produces bile acids to digest proteins and fatty acids in our small intestine .Statins are used to treat high cholesterol by inhibiting the synthesis of serum lipids and triglyceride.

    In this study ,only the HYDROPHOBIC statins(atorvastatin-Lipitor,simvastatin-Zocor,lovastatin-Mevacor and pitavastatin-Livalo) can provide the added benefit of induce apotosis and inhibit proliferation in cholangiocarcinoma cells.Other statins like Pravachol,cerivsatatin are hydrophilic and will not have the same benefit.
    The pre-treated cholangiocarcinoma cells with statins (in vitro) after 96 hours indicated that the future of inclusion of the statins in anticancer treatment regimens may reduce the amount of anticancer drugs used( such as 5FU,Gemzar and Cisplatin) and therefore the side effects that come along with them.
    God bless.

    #51202
    marions
    Moderator

    Hi Snezzie….definitely, we are seeing an increase of research.

    #51201
    snezzie
    Member

    That is fantastic.

    There ARE researchers and scientists trying so very hard for all of us.

    Thank you, Marion.

    Lesley

    #5339
    marions
    Moderator
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