Adoptive T-Cells vs CAR-T cell Therapy

What is adoptive T-Cell Therapy?
Adoptive T-cells transfer focuses on enhancing the body’s own T cells to fight cancer.

There are two main types of adoptive immunotherapy:

1. Adoptive Cell Therapy.
This involves collecting and isolating the tumor-infiltrating lymphocytes (T cells ) from a patient’s tumor, expanding them to large numbers and then re-administer to the patient.

2. Chimeric Antigen Receptor T-cells, also called CAR-T
Again, T- cells are collected from the patient’s tumor and re-infused in the patient. But unlike adoptive T-Cell Therapy, where the cells are grown in large numbers, CAR-T therapy involves engineering the T cells with new receptors. These new receptors recognize specific antigens on the surface of the cancer cells.
(What are antigens: a protein expressed by a bacteria or virus that is recognized by the immune system as foreign which can stimulate the production of antibodies and combine specifically with them)

In both cases the T cells multiply, seek and destroy the cancer cells that carry those specific antigens.

Both types of immunotherapy treatments are investigational. Patients must qualify to participate in clinical research studies.

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