Cholangiocarcinoma: treatment with sorafenib extended life expectancy

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Viewing 6 posts - 1 through 6 (of 6 total)
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  • December 5, 2013 at 6:42 pm #77625
    gavin
    Moderator

    You’re most welcome Mary. And you stay well too.

    Hugs,

    Gavin

    December 4, 2013 at 11:22 pm #77624
    mcwgoat
    Spectator

    Hi Gavin & Percy,

    Thanks once again for the valuable info you pass on to us!!!

    Stay well.

    Love & Peace,
    Mary

    December 4, 2013 at 6:54 pm #77623
    gavin
    Moderator

    Hi Percy,

    Thanks for that and for everything as well. And yes, the med professionals are indeed not patients. Hope you’re staying warm even though our Bears will be making you feel rather cold right now. Grrr to that and I though that this year would have been a good one for us…. Oh well, but it’s not over yet!

    For sure I’ll say hi to my mum from you. We had a physio round today showing her new breathing techniques for trying to get some of that stubborn phlegm up. It’s causing her big problems now. Was causing big problems before but a good bit worse these last few weeks. Majorly brrrrrr here now and a big storm on the way tomorrow too.

    Stay strong my friend and go Bears as always!

    Gavin

    December 4, 2013 at 5:59 pm #77622
    pcl1029
    Member

    Hi, Gavin,

    This exactly what I was told by Dr. Gores at Mayo that even the majority of patient may not response to Sorafenib beyond the short period of time of benefit; a sub set of patients can be of benefit from Sorafenib (a TKI-tyrosine kinase inhibitor)for a long time to control the cholangiocarcinoma .
    My guess is that other small molecules or antibodies (TKI & MoAB) will do the same. It just take time to find out the one that will be the best one to begin with. And NGS( next generation sequencing) gene profile will provide a foundation for such search if the oncologist is experienced on using this route.At this time, few treatments are really standing out,but at least better than going thru a lot of traditional chemotherapy without a personalized therapy in plan.
    I knew doctors and others may not agree on using this new technology to search for treatment, but there is one big difference ,the medical professional are not patients like us,we have a time limit and they don’t.

    Again, be sure to say hi to your mum for me, you are right , here in Chicago is as cold as the feet of the BEARS and the sky is cloudy, with no chance of going to playoff or meat ball.

    God bless.

    December 4, 2013 at 2:19 am #77621
    wallsm1
    Spectator

    Thanks for sharing!

    December 3, 2013 at 8:37 pm #9201
    gavin
    Moderator

    Cholangiocarcinoma: treatment with sorafenib extended life expectancy to greater than four years.

    http://www.ncbi.nlm.nih.gov/pubmed/24294517

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