I have a CT scan this week and I’m seeing my oncologist next week and I’m trying to prepare a list of treatment options to discuss (in case my Gem-Carbo chemo is not working). At the risk of going over what for many of you is “old ground” I’d be most grateful for your comments on the following (and anything I’ve missed). I’ve read and learned a lot on this website, and done some of my own research, what I need is to summarise the situation.
Are there any early results from clinical trials, or maybe just individual case reports, regarding the effectiveness of the drug in delaying disease progression and/or extending survival times in respect of CC or pancreatic cancer, for:
Approved in the US for colorectal cancer and apparently Caroline will get to receive it for CC. I’m not aware of any trials for CC or pancreatic. I believe the UK’s Royal Marsden hospital are conducting a trial of an alternative angeogenic drug, AZ2171, which they described to me as a “2nd generation avastin”.
Not sure whether this is “mainstream”. A lot of the reports about Davanat seem to come from the developer “Pro-Pharmaceuticals” and of course they have a commercial interest to promote.
There are phase-3 clinical trials under way but as far as I know these are “blind” trials so I guess results won’t be available until after the trials are completed. Not sure whether any stage-2 trials results are available.
The only positive reports I’ve seen relate to kidney cancer.
A chemo drug for colorectal and breast cancer. From what I read it’s no more effective that 5FU, just more convenient (it is oral) and less side effects. Caroline reported that she tried Xeloda without any success.
The subject of much research worldwide and possibly the definitive cancer treatment of the future. I have seen a recently published “report of a case” from Japan where a woman with CC was treated with surgery and post-op immunotherapy and, despite lymph node metastasis, she is still alive 3.5 years later. But I have not seen any reports of wider use of this form of treatment.
Again I’m looking for real evidence of effectiveness, which I recognise will probably not exist.
I recently met an oncologist in UK (a specialist in cancer vaccine research) who recommended the following which he said has been shown to shrink tumours:
Green Tea extract
Bromelain (an enzyme derived from pinapples)
Asprin (yes asprin!)
In addition have seen references to:
Active Hexose Correlated Compound (AHCC) – derived from mushrooms and the subject of an informal trial in Japan.
Fermented wheat germ extract – I’ve just seen Stacie’s post on this, and read a couple of the references, it sounds very promising.
Our father, who is 57, have been diagnosed with CC a few weeks ago. He has a Klatskin tumor, and the cancer has spread to the liver and stomach lining, wich makes an operation impossible. (Please forgive any errors in spelling, we are Norwegian so English is not our first language, and medical terms in English are new to us). I believe the cancer is stage 3, but this is not confirmed by his doctor.
The oncologist we have talked to wants to try chemotherapy as soon as the jaundice is better. His billirubin-values is improving slowly after three stents were placed a couple of weeks ago.
According to the oncologist the treatment wil be either a combination of Oxiliplatin and 5FU, or Gemzar.
Avastin is not commonly used on CC in Norway, and there are currently no clinical trials. Because of this it seems like he will not be treated with Avastin. Our impression is that it is quite commonly used on CC in the US and UK. We would like to find out how common it is, and more about results of any clinical trials of Avastin on CC. Does anyone have any advice or information regarding this?
Hilde, Stina and Ida.
As someone who has been following this company’s trials for several years I wanted to encourage everyone to visit the site of Pro-Pharmaceuticals to understand how their new “delivery system” works combat cancer.
For those of you who are new to the site I would recommend reviewing the VIDEOS section first as I feel it will allow you to quickly grasp the concept of DAVANAT, and then proceed to their press releases as it applies to the results of their HUMAN TRIALS to date. What I think you will find will amaze you and your Doctor.
What I think most will find amazing is that one person had their tumor reduced almost 50% in a case involving cancer of the colon, and in another case involving Cholangio Carcinoma, the person was alive 13+ months after begining treatment (they were only expected to live another 12 weeks. But please read the press releases in question.
I am not a doctor or an employee of the company, but I am someone who has lost a number of my family members to various cancers over the years. My intent here is to spread the word that there may be hope at last.
Topic: Davanat & 5FU
There is a new article out talking about the Phase II trial (Pro-pharmaceuticals) on Davanat and 5FU – I think Rick will post it today.
Is anyone participating in this trial and if so can you share some information – what has been the disease progression using this regimen, what are the side effects, etc.
Topic: Running Out of Options
My husband Frank (age 44) was diagnosed with cholangiocarcinoma in February 2005. He underwent surgery at Columbia Presbyterian in NYC in April 2005, endured radiation and 5FU for 7 weeks, followed by Gemzar and Oxyplatin which ended in December 2005. As of February 2006 his CAT scan was clean. On April 8, 2006 his CAT scan indicated 3 areas of cancer outside the liver. He then underwent a cholangiogram that revealed areas of blockage within the liver, all diseased with cancer. He now has the drainage tube to help relieve the liver and reduce the billiruben (in the 5’s range).
Eating solids has become extremely painful and can anyone tell us if it’s due to the liver beginning to fail and be able to break down solid food? Does anyone have suggestions after going through the same?
Also, he will begin palliative chemo on April 18th. Does anyone have other suggestions for us to try as we are getting down to the wire for treatment?
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Viewing 15 results - 571 through 585 (of 585 total)