Xeloda and oxilaplatin are also highly regarded therapeutic drugs for CC. Treatment choice has a lot to do with number of lesions, metastases, rate of growth, placement of primary lesions, etc. These treatment protocols are all new and emerging. At this point no one can say for sure that gemzar + cisplatin is superior to Xeloda + oxilaplatin, especially in your particular circumstance. It sounds like your doctor is trying to make the best choice for you personally. Good luck to you!
Violarob in Texas (NOT a doctor, just a heavy reader!
My doctor’s opinion is based on her experience, not studies. To my knowledge there are no studies that compare the two.
Anyways, I have matastic cc…it is concentrated in my stomach area, not in the bile ducts.
I am on xeloda and oxilaplatin. I wish there was a study that compared the results. My doctor doesnt reallly seem too interested in changing my regime. She says that from her experience, the two that I am on work best. I am so confused.
I have personal experience with this, too. I had gemcitabine + cisplatin last year, with very good result. A few months after my RF ablation procedure, they put me on gemcitabine alone as “maintenance” therapy to try to keep from having a relapse. Well, the gemcitabine alone did not do the trick; the cancer came back.
You are right; gem + cisplatin seems to be emerging as the standard of care, (with some oncologists adding Tarceva, or Avastin or Xeloda, depending on the individual patient situation.)
Vilarob…that seems to be the general consensus although, some are still awaiting to some of the raw data. The multinational study has caused quite a stir in the medical community. It was the largest study ever conducted and it has all the indication of becoming a first approved standard of care of CC patients.
Thanks for posting this, Marion. The study was authored by Dr. Kaseb, one of the GI oncologists at MD Anderson. They are discovering that gemcitabine + cisplatin is much more effective than gemcitabine alone.