ABC 03 Trial – recruiting September time

Looks like trial has been put back until March 2011. Hopefully this will help CC patients in the future.

Trial Name (Short): ABC-03 Trial Name: Randomised phase II trial of cediranib (AZD2171) vs. placebo in addition to cisplatin / gemcitabine chemotherapy for patients with advanced biliary tract cancer Description: This phase II trial builds on the ABC-02 trial in which patients were randomised to gemcitabine alone or gemcitabine plus cisplatin (CisGem). The CisGem arm showed a 3.5 month survival advantage and a 2 month progression free survival advantage.

In ABC-03, the aim will be to see if adding cediranib to CisGem will be more effective than CisGem alone. Cediranib is an unlicensed VEGF inhibitor. This trial is part of the NCRN/AstraZeneca collaboration

Trial Status: In set-up
Trial Coordinator: Elka Humphrys Email Contact: Email Trial Summary: Opening Date: 01/03/2011 (Estimated)
Recruitment Target: 136 Funder: CRUK & AstraZeneca
Chief Investigator: Dr Juan Valle

Page last updated on 11/01/2011 by Colin Lunt

Kate,

I have been keeping on top of this and the date has been put back until 28 November. Hopefully Dad will be sorteby then but if not it is something I will mention.

Thanks

Hi Julia,

Dad had his blood tested today so will know Monday if bilirubin has gone up or down. I think it’s gone up as his eyes have a slight yellow tinge starting to appear.

The next step will be his stent being unblocked, he may have to go to another hospital for this if they can’t slot him in at the birmingham hospital Because dad feels well I think he’d prefer to wait for Birmingham to do it but i’ve told him it’s important to have his stent unblocked so chemo can start and the longer he wiats the longer it will take to come down. They won’t start at anything above 50 as the normal limit is 35. Even if they can see it is going down 50 is the magic number!

The good thing is the doctor and nurses were pleased to see dad looking well (apart from slight eye tinge!) and eating well, I hope this continues.

Thank you for thinking of us.

Best wishes to you and your family

Hi Julia.

I’ve just read your other post, so pleased your sister is doing so well, it’s wonderful news to hear.

My Dad is feeling very well and is carrying on with all normal day to day activities. You wouldn’t know he had CC if you hadn’t been told.

The main problem is the Chemo, or lack of! We went to see the Oncologist today and he’s referring Dad back to the liver hospital as his bilrubin is still too high for chemo (75). We have got to go Friday to see what they say. I presume it will be due to a blocked stent. Dad is getting anxious now though that he was diagnosed and stented in April and he still hasn’t has any treatment. Fingers crossed they can sort out the stent and start Chemo soon.

Best wishes to you and your sister.

Hi Gavin,

No problem it’s a pleasure to try and help.

I was hoping my Dad would be able to take part as originally it mentioned a June start but an email I received today mentioned it would be recruiting in September, so it will be too late as Dad will need to start his Chemo before then.

Hopefully it will be of help to someone.

It I recieve anymore emails regarding the trial I will update

Best wishes