Activated macrophages promote Wnt/β-catenin signaling in cholangiocarc

Activated macrophages promote Wnt/β-catenin signaling in cholangiocarcinoma cells.

“In conclusion, the present study reports the abundant expression of Wnt protein family and β-catenin in CCA as well as the effect of inflammatory condition on Wnt/β-catenin activation in CCA cells. Importantly, abrogation of β-catenin expression caused significant CCA cell growth inhibition. Thus, the Wnt/β-catenin signaling pathway may contribute to CCA cell proliferation and hence may serve as a prognostic marker for CCA progression and provide a potential target for CCA therapy.”

http://www.ncbi.nlm.nih.gov/pubmed/24549785