Adjuvant therapy for lymph nodehilar cholangiocarcinoma??

Discussion Board Forums General Discussion Adjuvant therapy for lymph nodehilar cholangiocarcinoma??

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  • #92952
    marions
    Moderator

    juliet…..welcome to our special group. The adjuvant treatment described by you is not known as chemoembolization and has shown quite successful with some. My first inclination is for you to obtain a second, professional opinion from a center treating a high volume of cholangiocarcinoma patients.

    You may want to reach out to the Taiwan Cooperative Oncology Group, TCOG
    http://english.nhri.org.tw/NHRI_WEB/nhriw001Action.do?status=Show_Data&uid=20110614402841800000

    I believe that the recurrent fever must be brought under control, as it will prevent any proposed treatment regimen and assume that the physicians will re-evaluate any treatment post 2 to 3 months recovery from present surgery.

    Hoping for others to chime in on this conversation.

    Hugs,
    Marion

    #12682
    julietsai24
    Spectator

    My mother was 61 years old. She has hilar cholangiocarcinoma. The pathology from operation is T2a, N1 and adjuvant chemotherapy was suggested. We visited the doctor this Wednesday. The doctor told us that my mother should receive chemotherapy within 6-8 weeks after the operation. He recommended us to use intra-arterial infusion chemotherapy. He would put an artificial vessel over celiac trunk artery, so the chemo-drug can infuse directly to the tumor region. The treatment would be 6 cycle(once per 3 weeks) with 3 combined drugs(gemcitabine, cisplatin, 5-FU). He told us that the regimen can acheive 40-50% control rate. He would also start the immuno-cellular therapy at the same time(stimulate the patient’s T cell by her own dendritic cell which has interacted with cancer cell first , then proliferate the antigen specific T cells and re-infuse them from the artery). The T cells should be injected in the period of 7 days before and after chemotherapy, or else the T cells would be killed by the chemo-drug.
    Now, I’m quite worry about the side effect of chemo-drug, since 3 kinds of drug was used at the same time. Could anyone share your chemo-experience?? Actually, we are still hesitate whether to receive the chemotherapy or not. Because my mother has been very weak after the operation(She is quite good before the surgery). It has been 4 weeks after the surgery. However, fever is still noted. The doctor said that recurrent cholangitis is inevitable due to reconstruction of bile duct with intestine.
    We’re also seeking for nutrition therapy. Do anyone have any information to this?? Thankyou very much:)

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