Agios to Present Clinical Data from Ongoing AG-120 Phase 1 Trial

Discussion Board Forums Clinical Trials Agios to Present Clinical Data from Ongoing AG-120 Phase 1 Trial

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  • #90261
    marions
    Moderator

    Here is the long awaited data from the ongoing Phase I A-G 120 trial for IDH-1 advanced patients who previously had been treated with one or more therapies.

    There is no further enrollment for the dose escalation and expansion cohort, but those enrolled in Phase 1 will continue to be assessed for safetey and tolerability.

    Stable disease was observed in 56% of patients
    Partial response was observed in 5% of patients

    Hugs
    Marion

    #90260
    marions
    Moderator

    deadlift…..Cerena’s mother and our Matt had spectacular results with Keytruda. You may want take at Matt’s postings:

    http://www.cholangiocarcinoma.org/punbb/search.php?action=show_user_posts&user_id=10126

    Hugs,
    Marion

    #90259
    deadlift
    Participant

    I realize I wasn’t super clear. So trial was over a few months ago, so they kept her on ag120 since she was responded. Back in January she went from shrinkage to stable , last week she went from stable to growth. She is now visiting friends in Colorado and will start keytruda once they schedule all of that. All these treatments all seem to be , could shrink then not. Could go remission , or could do nothing.

    Thanks for the kindness here

    #90258
    marions
    Moderator

    deadlift…..what were the reasons for the drop out of this trial?

    Hugs
    Marion

    #90257
    deadlift
    Participant

    Wife out of trial. On to keytruda sounds like.

    #90256
    marions
    Moderator

    deadlift…..perfect. Regular bowel movements are extremely important. Some people do best with small meals spread throughout the day. Some use stool softeners prior to meal intake. Moving around following meal intake also can be beneficial.

    Hugs
    Marion

    #90255
    deadlift
    Participant

    Seems like that was 2 weeks of constipation pain She changed meds to mirilax and changed her diet and seems back to pre pain levels or energy. Or a little less

    #90254
    marions
    Moderator

    deadlift……it’s tough to distinguish the cause of abdominal pain, but even I have the tendency to attribute anything to this cancer.
    What I have learned though is to wait until all information comes in. That’s tough to do and surely I did not practice it while my husband was battling this cancer.

    Hugs
    Marion

    #90253
    deadlift
    Participant

    Thanks marions. Thag helps and makes stable sound more positive. Though this last week wife has new abdominal pain. She went back on oxy and that doesn’t seem to help. Waiting to hear back from her doctor when the work week starts. Went to er last night to make sure it want anything else and they couldn’t find anything and sent her home.

    The only positive spin was her cousin was just in the hospital with severe abdominal pain and heh called it a virus and sent him home. Hopefully that’s it cause we saw him a few days after he felt better.

    #90252
    marions
    Moderator

    deadlift…..This subject comes up often. Tumor is considered stable and yet is determined active in a follow-up scan. Stable tumor – what does it mean?

    Imaging Response Criteria

    •CR (complete response) = disappearance of all target lesions
    •PR (partial response) = 30% decrease in the sum of the longest diameter of target lesions
    •PD (progressive disease) = 20% increase in the sum of the longest diameter of target lesions
    •SD (stable disease) = small changes that do not meet above criteria

    http://imaging.cancer.gov/clinicaltrials/imaging

    You are correct, this is a roller coaster ride. Your wife’s follow-up scans will provide important information re: her response to current treatment.

    Research trials provide patients the ability to “possibly” benefit from a drug still under investigation.
    So, we really don’t know how each person responds beforehand.
    Just know that other treatments are available if and when needed.

    Hang in there. We are rooting for you.

    Hugs
    Marion

    #90251
    deadlift
    Participant

    Well wife had her first scan in oct , shrinkage , scan in nov also had shrinkage. She didn’t tell me about The scan in dec . She wasn’t feeling as good last week which I attributed to not eating properly. Well latest scan has shrinkage and growth but over all stable whatever that means. She does get to stay on the trial which I think is good overall but seems like back to the roller coaster. I guess sometimes this works sometimes it doesn’t and sometimes it stops working ?

    #90174
    marions
    Moderator

    bostonguy…..I too lost my loved one to this cancer (2007) and know and understand your pain.
    May your heart begin to heal, one day at a time.

    Hugs and love
    Marion

    #90176
    darla
    Participant

    Dan,

    So sorry for your loss. You and your family have my deepest sympathy.

    Darla

    #90175
    googily
    Member

    My most sincere condolences to you and your family. Losing your mother is so terribly hard.

    #90173
    bostonguy
    Member

    Thank you to all of you for your kind thoughts and prayers. She passed away peacefully late last night with me and my sister resting on her shoulders. We are directing donations to the Dana-Farber cholangiocarcinoma research fund with the hope that perhaps it can be of help to someone in the future.

    This forum has been very helpful to me. As a physician, I actually thought I would not get anything out of an internet forum about medical stuff. I was very wrong. Thank you to all of you for being there for my family.

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