Rita……when using the google search using: “abstract, avastin, cholangiocarcinoma” you will be able to pull up several abstracts concerning the use of Avastin in combination with other chemotherapies. Also, our search function is useful in pulling up prior postings in re: to Avastin. There is some controversy regarding the long term usefulness of Avastin, which may or may not be the reasons for a possible denial of this drug. By reading through previous threads on this site you will notice for some people not receiving approval from their insurance company wheras others have not experienced any problems at all. Either way, there are plenty of studies proven the efficiacy of Avastin and you should not have any problems presenting these to the physician treating your brother in law. Others may have more tips and hints in re: to fighting the insurance company for approval. Good luck to you. Sending my best wishes to your brother in law.
Marion