Chemotherapy and You

Discussion Board Forums Chemotherapy & More Chemotherapy and You

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  • #89540
    marions
    Moderator

    You are welcome, dear positivity.

    #89539
    positivity
    Participant

    Thank you for this thorough response.

    #89538
    marions
    Moderator

    positivity….
    Research is focused on Immune checkpoint inhibitors and targeted drugs. Molecular testing is of great importance to our patients as it may reveal certain alterations for one or the other (or both) is applicable.
    Presently none have been approved for our cancer, but there are many research studies combining targeted drugs with immonotherapy agents, targeted drugs with various radiation treatments, immunotherapy and/or targeted drugs with cytotoxic (chemo) agents and the list continues to grow.

    Additionally, the expanded access, also called “compassionate use,” provides a pathway for patients to gain access to investigational drugs, biologics and medical devices for serious diseases or conditions.
    Investigational drugs and devices have not yet been approved by the FDA and they have not been proven to be safe and effective. Therefore, they may be effective in the treatment of a condition, or they may not. It is important to remember that the drug/biologic/medical device may have unexpected serious side effects and that patients need to consider all the possible risks when seeking access to an investigational medical product.
    http://www.fda.gov/ForPatients/Other/ExpandedAccess/ucm20041768.htm

    Nearly all pharmaceutical companies provide expanded access to patients.

    Personalized Medicine:
    We are in the era of personalized medicine, a form of medicine that uses information about a person’s genes, proteins, and environment to prevent, diagnose, and treat disease. In cancer, personalized medicine uses specific information about a person’s tumor to help diagnose, plan treatment, find out how well treatment is working, or make a prognosis. Examples of personalized medicine include using targeted therapies to treat specific types of cancer cells, such as HER2-positive breast cancer cells, or using tumor marker testing to help diagnose cancer. Also called precision medicine.
    https://www.cancer.gov/publications/dictionaries/cancer-terms?cdrid=561717

    Hugs,
    Marion

    #89537
    positivity
    Participant

    When I suggested to one oncologist for a molecular test, he did not recommend it since the cancer has not spread. Does this sound ludicrous? Am I missing something here? I thought this is a test to determine what is the cause or best treatment plan for the cancer. Is there a reason why the doctor would want to avoid this test? Again, the patient has not undergone treatment and trying to determine the best option.

    #89536
    marions
    Moderator

    These tests are performed in a laboratory. Cells taken from the tumor are mixed with certain chemotherapy agents. The results are identification of sensitivity to these drugs.

    Yes, we had this done 10 years ago, but it helped us little as at that time, few drugs were available.

    Can anyone report on success with this test?

    Hugs
    Marion

    #89535
    alikemal
    Participant

    what is Chemosensitivity test ? Did you experience it ?
    Thank you in advance.

    #89534
    marions
    Moderator

    Beatriz….so sorry, I missed this post.

    To answer your question: Oncologists are not required to conduct molecular testing, but most will recommend it. Patients can request molecular testing independently. In this case they physician fills out the required form and initiates mailing of tissue sample to an independent lab such as Foundation One.
    Enrollment in the ASCO TAPUR study is handled the same. Your physician will forward lab analyses to the TAPUR coordinator.

    The NCI MATCH trial is handled differently in that a new biopsy must be performed and the tissue is then analyzed by their independent lab.

    Blood chemo and natural sensitivity blood test are different in than molecular testing reveals genomic abnormalities in your tumor, if such are present.

    Chemosensitivity tests may help predict whether the tumor is resistant to chemotherapy.

    Hope this helped.

    Hugs,
    Marion

    #11636
    marions
    Moderator

    http://www.cancer.gov/publications/patient-education/chemo-and-you

    Family and friends may also want to read this booklet. This booklet is a guide you can refer to throughout your chemotherapy treatment. It includes facts about chemotherapy and its side effects. It highlights ways you can care for yourself before, during, and after treatment.

    You may order this booklet by calling: 1-800-4-CANCER (1-800-422-6237)

    You may also want to read the e-version using this link:
    http://www.cancer.gov/publications/patient-education/chemotherapy-and-you.pdf

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