Mark has been on both. He was on 5FU for a couple of months, but you are right, it was more difficult to be hooked up for two days. The difference is that Xeloda, which he takes now, is in pill form and is a little harder on the liver (the liver has to process it) and most patients don’t want to stress the liver any more than it already is, however, our oncologist was not concerned about this, he said this was minimal if any. Xeloda does appear to have different side effects than 5FU as well.
Mark has tolerated the Xeloda very well and has had very few down days as compared to his other regimens. If you need more details you can look at the published works on both 5FU and Xeloda on pubmed
Hope this helps.
Stacie