Garlic and allicin

Discussion Board Forums General Discussion Garlic and allicin

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  • #100873
    bglass
    Moderator

    Hi BillM,

    Thank you for sharing this.  There seem to be many medical journal articles looking at the anti-cancer properties of garlic.  From what I read, there is no specific evidence yet that eating garlic can affect outcomes with our cancer – that study has not yet been done so far – but certainly pursuing a healthy diet with foods thought to carry anti-cancer or anti-inflammation benefits is a good plan for cancer patients.

    There was a study a few years ago that attracted attention in the cancer world that showed a positive correlation between consumption of tree nuts and outcomes for a sample of colon cancer patients.  When I saw this, I added tree nuts to my daily diet.  I have no idea if this has helped me cancer-wise but nuts are nutritious and they taste good.  If you internet-search tree nuts and colon cancer, you can find references to this research.

    I hope you are well and thank you for contributing to our community.

    Regards, Mary

    #100872
    BillM
    Participant

    https://www.frontiersin.org/articles/10.3389/fphar.2019.01614/full

    Allicin in elephant garlic (what you normally get in the store) is about 1/4 as potent as real garlic. Siberian garlic has the most allicin from what I have read.

    Allicin, one of the main organic allyl sulfur components in garlic (Allium sativum, Amaryllidaceae), was examined for its effects on cholangiocarcinoma (CCA) (Chen et al., 2018). In BALB/c nude mice model of CCA, allicin (10 mg/kg) significantly suppressed the growth of human liver bile duct carcinoma (HuCCT-1). The in vitro molecular study showed that allicin (20 µM) reduced the levels of matrix metalloproteinase (MMP)-2 and -9, via reducing the activity of the STAT3 signaling pathway to decrease migration, invasion, and epithelial-mesenchymal transition (EMT) of HuCCT-1 cell. Additionally, allicin suppressed proliferation by activating the caspase cascade, inducing apoptosis, and reducing the expression of proteins downstream of STAT3, such as B-cell lymphoma 2 (Bcl-2), while upregulating Bcl-2-associated X (Bax) protein (Chen et al., 2018). Subsequent studies, showed that allicin (5 µM) altered TIMP/MMP balance, via reducing the activity of the PI3K/AKT signaling pathway thereby significantly inhibiting adhesion, invasion, and migration of lung adenocarcinoma A549 and H1299 cells (Huang et al., 2017).

     

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