How would the doxorubicin be administered? by infusion in the arm, hepatic artierial infusion or chemoembolization? These 3 methods are very different as to side effects and effectiveness of treatment. Doxorubicin is a very rough drug, and is not particularly effective for cholangio. Gemzar is more effective but is used more as a stabilizing drug rather than a tumor-shrinking drug.
With a tumor that large, I am surprised they are not recommending some kind of resection or ablation to reduce the size before initiating a chemo regimen.
I am not a doctor, so get lots of opinions! Good luck, and keep us posted on your progress.