Genomic Profiling of Intrahepatic Cholangiocarcinoma: Refining Prognos

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  • June 7, 2014 at 5:37 am #82789
    gavin
    Moderator

    Thanks for that Jason and Judy.

    June 6, 2014 at 8:05 pm #82788
    judym
    Member

    See also:

    http://www.agios.com/pipeline-idh.php

    June 5, 2014 at 3:20 am #10120
    jscott
    Member

    Genomic Profiling of Intrahepatic Cholangiocarcinoma: Refining Prognosis and Identifying Therapeutic Targets.

    http://www.ncbi.nlm.nih.gov/pubmed/24889489

    Interesting abstract (the paper is paywalled). It reports the incidence of the IDH1 mutation in ICC as 15.5% based on 200 tumor samples. It also said that patients with “bilateral” tumors, which I understand to mean tumors in both liver lobes, have 2.75 times the likelihood of having the IDH1 mutation. That is starting to get reasonably likely for that type of patient.

    Hopefully the IDH1 trial will fill and show a lot of promise.

    Great news out of that trial would be fantastic.

    Jason

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