(IDH1 and CRISPR tech) R-2HG downregulates ERα to inhibit cholangiocarcinoma

Discussion Board › Forums › New Developments › (IDH1 and CRISPR tech) R-2HG downregulates ERα to inhibit cholangiocarcinoma

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  • October 16, 2021 at 8:49 pm #101326
    Hannaha
    Spectator

    I also came across this study. It’s very dense but what I get from it is that scientists are using CRISPR technology to create IDH1 cells and then use them to effect tumor growth pathways. I am hoping this means good news for more advances in exploiting IDH1 mutant CCA avenues for treatment and other mutations as well!

    R-2HG downregulates ERα to inhibit cholangiocarcinoma via the FTO/m6A-methylated ERα/miR16-5p/YAP1 signal pathway

    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8479483/

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