Discussion Board Forums Clinical Trials My sister starting PDL1 immunotherapy trial at UCSF this week!

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  • #83242
    mbachini
    Moderator

    I know that I have heard the docs at NIH talk about this treatment and the excitement of the prospects…..I also know that it is considered as one of my backup plans. I am hoping not to have to have a back up plan but boy oh boy it is comforting to know there will be another option!!
    Melinda

    #83241
    gavin
    Moderator

    Thanks for these Jason, very useful. Here’s another few –

    http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3518493/

    #83240
    jscott
    Member

    The whole pd-1/pd-l1 was very confusing to me, but I found this article helpful in understanding the pd1 / pd-L1 interaction:

    http://www.medscape.com/viewarticle/810688_3

    If I read this right, MK-3475 is a pd-1 inhibitor. There are also trials looking at pd-L1 inhibitors. The Merck drug for anti pd-L1 is MSB0010718C. A trial with this drug is described here:

    http://clinicaltrials.gov/ct2/show/NCT01772004

    Both approaches are trying to stop the pd-1/pd-L1 interaction (which turns off the immune response). All very very exciting.

    I hope your sister has a fantastic response.

    Best,

    Jason

    #83239
    gavin
    Moderator

    My fingers are crossed for your sister Willow, I so hope that the trial goes well.

    Hugs,

    Gavin

    #83238
    marions
    Moderator

    Julie…this is the trial:
    http://clinicaltrials.gov/ct2/show/study/NCT02054806?show_locs=Y#locn
    it is opened in select US centers as well as Europe and South Korea.
    Scroll to bottom of page for direct location information.
    Hugs,
    Marion

    #83237
    jathy1125
    Participant

    Willow, you are an amazing sister, your sister is so blessed to have you as one of her caregivers!!
    Lots of prayers for HOPE and miracles-Cathy

    #83236
    willow
    Participant

    Thanks everyone for your support. We really need it now! Friday was her first infusion. My sister is so ill and has new signs and symptoms of advanced cancer almost daily, so I am a nervous wreck more and more.
    Judy, the trial is the MK/3745 anti PDL/PDL1 trial at UCSF for solid tumors. Yes, tissue must be tested to see if tumor has the PDL mutation. About half if CC cancers carry that mutation.
    Nicole’s first infusion went well though she had nausea oping this drug slows the cancer and brings relief. on ride home and diarrhea soon after. Fatigue too, though it’s hard to tell what is causing that as so many things do at this point. By yesterday (2 days after infusion), she had de van itchy rash all over her belly. Hoping this is not an allergic reaction but more of a sign her immune system is waking up to fight the CC. Will talk to the dr today.
    She will be able to have labs and scans at Stanford and the trial mandated dr visits /infusions at UCSF. Infusions every other week. Scans every 8 weeks.
    Her 10 year old son spent the weekend with us (2 hours away) and it was a precious time for me. Gave my sister and brother in law time to rest and catch their breath.

    #83235
    mbachini
    Moderator

    Willow, that is such awesome news! Praying for great results! Melinda

    #83234
    judym
    Member

    Very interesting. Is genetic testing required to determine eligibility and if so, what specific genes are being looked for? Do you know what the trial # is?

    #83233
    gavin
    Moderator

    Hi Willow,

    This is excellent news indeed! Thanks for that. I so hope that thelabs come back good and that it is all things go for your sister with this trial! The results from trial for MK-3475 for metastastic melanoma seem to be very good so let’s hope that this can be applied for CC as well. Got everything crossed for your sister and please let us know how she gets on with this. Good luck to her!

    Hugs,

    Gavin

    #83232
    iowagirl
    Member

    Willow….will be praying for good labs.

    #83231
    lainy
    Participant

    Wow, WIllow this sound extremely interesting and I will be crossing everything I own for the best news!

    #10221
    willow
    Participant

    Officially, this immunotherapy trial is MK-3475
    It is also known as PDL1 monoclonal antibody therapy. Programed Death Ligand (PDL)
    takes cancer’s “cloaking” mechanism away so your own immune system will recognize cancer as foreign and attack it.
    Phase 1 Trial at UC San Francisco
    Been tested at other sites and shown promise/effectiveness in other cancers with the same mutation, in particular in melanoma and non-small cell lung cancer. Drug companies scrambling to be first to develop this drug and they want to see if it’s effective in other cancers (with same PDL1 mutation).

    It took over a month to get results from genetic mutation testing so better to be proactive if you’re thinking of trying any of these targeted therapies in the future. This delay could mean that she no longer qualifies based on the stability of her health/liver enzymes/platelets etc.
    My sister had her labs today, will have her screening physical tomorrow and first infusion Friday, if she “passes” the screening labs/physical.
    Willow

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