July 1, 2014 at 7:05 pm #83242mbachiniModerator
I know that I have heard the docs at NIH talk about this treatment and the excitement of the prospects…..I also know that it is considered as one of my backup plans. I am hoping not to have to have a back up plan but boy oh boy it is comforting to know there will be another option!!
MelindaJuly 1, 2014 at 5:38 pm #83241
Thanks for these Jason, very useful. Here’s another few –July 1, 2014 at 12:48 pm #83240jscottMember
The whole pd-1/pd-l1 was very confusing to me, but I found this article helpful in understanding the pd1 / pd-L1 interaction:
If I read this right, MK-3475 is a pd-1 inhibitor. There are also trials looking at pd-L1 inhibitors. The Merck drug for anti pd-L1 is MSB0010718C. A trial with this drug is described here:
Both approaches are trying to stop the pd-1/pd-L1 interaction (which turns off the immune response). All very very exciting.
I hope your sister has a fantastic response.
JasonJuly 1, 2014 at 5:06 am #83239
My fingers are crossed for your sister Willow, I so hope that the trial goes well.
GavinJune 30, 2014 at 11:32 pm #83238marionsModerator
Julie…this is the trial:
it is opened in select US centers as well as Europe and South Korea.
Scroll to bottom of page for direct location information.
MarionJune 30, 2014 at 10:22 pm #83237jathy1125Participant
Willow, you are an amazing sister, your sister is so blessed to have you as one of her caregivers!!
Lots of prayers for HOPE and miracles-CathyJune 30, 2014 at 3:02 pm #83236willowParticipant
Thanks everyone for your support. We really need it now! Friday was her first infusion. My sister is so ill and has new signs and symptoms of advanced cancer almost daily, so I am a nervous wreck more and more.
Judy, the trial is the MK/3745 anti PDL/PDL1 trial at UCSF for solid tumors. Yes, tissue must be tested to see if tumor has the PDL mutation. About half if CC cancers carry that mutation.
Nicole’s first infusion went well though she had nausea oping this drug slows the cancer and brings relief. on ride home and diarrhea soon after. Fatigue too, though it’s hard to tell what is causing that as so many things do at this point. By yesterday (2 days after infusion), she had de van itchy rash all over her belly. Hoping this is not an allergic reaction but more of a sign her immune system is waking up to fight the CC. Will talk to the dr today.
She will be able to have labs and scans at Stanford and the trial mandated dr visits /infusions at UCSF. Infusions every other week. Scans every 8 weeks.
Her 10 year old son spent the weekend with us (2 hours away) and it was a precious time for me. Gave my sister and brother in law time to rest and catch their breath.June 30, 2014 at 6:35 am #83235mbachiniModerator
Willow, that is such awesome news! Praying for great results! MelindaJune 26, 2014 at 3:14 am #83234judymMember
Very interesting. Is genetic testing required to determine eligibility and if so, what specific genes are being looked for? Do you know what the trial # is?June 25, 2014 at 5:32 am #83233
This is excellent news indeed! Thanks for that. I so hope that thelabs come back good and that it is all things go for your sister with this trial! The results from trial for MK-3475 for metastastic melanoma seem to be very good so let’s hope that this can be applied for CC as well. Got everything crossed for your sister and please let us know how she gets on with this. Good luck to her!
GavinJune 25, 2014 at 1:48 am #83232iowagirlMember
Willow….will be praying for good labs.June 24, 2014 at 11:31 pm #83231lainyParticipant
Wow, WIllow this sound extremely interesting and I will be crossing everything I own for the best news!June 24, 2014 at 11:06 pm #10221willowParticipant
Officially, this immunotherapy trial is MK-3475
It is also known as PDL1 monoclonal antibody therapy. Programed Death Ligand (PDL)
takes cancer’s “cloaking” mechanism away so your own immune system will recognize cancer as foreign and attack it.
Phase 1 Trial at UC San Francisco
Been tested at other sites and shown promise/effectiveness in other cancers with the same mutation, in particular in melanoma and non-small cell lung cancer. Drug companies scrambling to be first to develop this drug and they want to see if it’s effective in other cancers (with same PDL1 mutation).
It took over a month to get results from genetic mutation testing so better to be proactive if you’re thinking of trying any of these targeted therapies in the future. This delay could mean that she no longer qualifies based on the stability of her health/liver enzymes/platelets etc.
My sister had her labs today, will have her screening physical tomorrow and first infusion Friday, if she “passes” the screening labs/physical.
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