Overexpression of membrane metalloendopeptidase inhibits substance P-s

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    gavin
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    Overexpression of membrane metalloendopeptidase inhibits substance P-stimulation of cholangiocarcinoma growth.

    “The study suggests that SP secreted by CCA promotes CCA growth via autocrine pathway. Blockade of SP secretion and NK1R signaling may be important for the management of CCA.”

    http://www.ncbi.nlm.nih.gov/pubmed/24603459

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