Duke,
I have had this both ways.
First, I had day one of a round of Gem/Cis and then couldln’t do the day 8 because of blood clots and hospitalization. They treated it the same as a full round ….including the week three off and started Round 2 as if Round 1 had been completed. Both my local oncologist and the Mayo oncologist suggested doing it this way.
Just recently, I was ready for Round 6, but requested that we sit a week out and to let blood counts come back up …or hope they did, before doing the day one of Round 6 chemo. They had no problem with that,….said that it is done all the time. In addition, I had reduced dosage because of kidney issues.
I agree with Jason….shifting a day or two won’t do anything negative if that is a possibility for the time away you had planned.
Otherwise, for my part…..having just had that extra week off ….that is….a 4th week in a round instead of 3, I can tell you, it made a huge difference in how I felt and allowed my blood counts t to come back up ….especially my hemoglobin, which actually rose .7 . I needed that at that week off to reset my organs’ functioning or I probably wouldn’t have been able to do this 6th and last round. (which ends with the last infusion on Wednesday next week).