Joviony,
I am sorry to hear your wife is experiencing pain around her port. In my own case, after I was past the initial pain from the port being installed which lasted about a week, there were subsequent episodes of soreness that occurred with daily activities. For example, some sleeping positions really irritated my port and the car seatbelt was most unfriendly. When the irritant passed, the discomfort largely went away within maybe 30 minutes or an hour. The discomfort was both at the port site and sometimes in my neck. Only once did it get so painful that I called the nurse, and her advice was similar to what your wife was told – probably nothing to worry about but call back if it got worse. What I experienced was more discomfort and soreness, however, rather than serious pain.
I am not a doctor, but my recollection of the advice I was given was to report any concerning pain to the nurses in the oncology department where I was treated. If I had experienced more severe pain that did not go away, my instinct would have been to push for an appointment for my medical providers to take a look.
I both loved and hated my port. It did make the chemo easier.
I hope this is helpful.
Regards, Mary