Road Map & Systemic CCA Chemotherapy,Targeted Therapy & Options
- This topic has 48 replies, 14 voices, and was last updated 8 years, 11 months ago by
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Marion and Lisa,
Thank you both so much for the response and guidance. This family here is really quite incredible, and I’m so thankful to have all of your support.
Lisa, you are so brave, and thank you for the offer to help. I will give you a call later today! Thanks!!
Julie
Julie, I had two liver resections and chemo. I have had a total of 8 tumors. The last several small ones have been effectively destroyed by steriotactic radiation. If you have any questions about this treatment feel free to call me at 330-903-6868.
LisaJulie…I am sure that Percy would respond however; at the moment he is visiting his home country. Forgot his return date, but I believe it is at the end of this month. Please make sure to address him again as soon as you see his postings appear on this site.
Hugs,
MarionPercy,
Thank you SO much for this information. I am new to this site and have found so much of the posts’ info to be incredibly helpful, including this one.
My Dad’s ICC recurred earlier this year (Jan 2013) after he had a resection in March 2012. We are going to see the oncologist at UCLA tomorrow to discuss treatment plans, and I’ve found this info you posted to be a great resource. I’m preparing a list of questions to ask the oncologist tomorrow, and I wonder if you have suggestions for what we definitely should be asking.
Just a quick background on my Dad’s situation – he is 63, had a 5cm tumor resected from his right lobe in March 2012, and two new lesions (~1cm each) popped up on segment 7 and 4/8. He’s otherwise healthy, has a great appetite and is active.
His main symptoms are skin itchiness which has mostly subsided after he started paying more attention to the foods that he eats. I know there aren’t any western medicine protocols for nutrition in the recovery process, but we’ve started reading up a lot on nutrition after he started realizing that certain foods just made him feel so much better and since then his skin itchiness has been very infrequent. Sorry I’m rambling. As I was saying earlier, I’d love to hear your thoughts on relevant questions to ask the oncologist. Our oncologist is nice, but he’s really hard to connect with – I always feel like I need to ask him the right questions or else we don’t get all the necessary information.
Thanks!!!!!
Julie
Hi, everyone,
To make this discussion” Systemic Chemotherapy in general for CCA”
It fits to include this link.The link below included most if not all chemotherapy and targeted agents and regimens with the intention to treat cholangiocarcinoma.
http://www.cholangiocarcinoma.org/punbb/viewtopic.php?pid=70877#p70877
God bless.
Hi,
if you are interestedConclusions by the author: This dosing schedule of FDR gemcitabine plus capecitabine is active in patients with advanced pancreatobiliary cancers. Given its favorable toxicity profile and convenience, this regimen represents an appropriate front-line option for this patient population and may serve as the foundation on which new investigational agents are added in future trial design.
http://www.oncologystat.com/journals/journal_scans/Role_of_Gemcitabine_Based_Combination_Therapy_in_the_Management_of_Advanced_Pancreatic_Cancer_A_Meta_analysis_of_Randomised_Trials.html
“Interpretation by the author.”
The combination chemotherapy as compared to gemcitabine alone significantly improves OS in advanced pancreatic cancer (APC). However, this advantage is marginal whereas the treatment-related toxicity is increased, suggesting the use of gemcitabine-based combination regimens only in selected patient populations. New prospective trials, based on translational approaches and innovative validated biomarkers, are eagerly awaited on this topic.P.S. Even it is not for CCA,but as you all know , most of the regimens,if not all,for CCA are coming from pancreatic cancer protocols with variations.
God bless.
Hi, everyone,
and for those who are new here; I finally finished the revision of “Systemic treatment in general for cholangiocarcinoma patient.”
I have added “side effects” and “drug-drug interactions” to cetuximab, Avastin, Gemzar and irinotecan among others.
Please remember,it is just used for references ,therefore you may or may not get any side effects for the chemotherapy agent you take.It is an individual thing for each patient. with regard to the regimens and protocol,remember oncologist can change it to fit the need of the patient, and this is why we ,as patients, need to see the doctors .
God bless all of you.Kaklon, you know it, you did come to the right place to learn, advise or even vent. We are family here and I don’t know of a more courageous, loving and caring family that comes from all over the world. I wanted to ask you where Ashland MO is as I was born and raised in Kansas City Mo many years ago!
This is an amazing amount of information and I am grateful to have it at my fingertips. It is also overwhelming, trying to absorb and digest so much, so fast as I am relatively new to the diagnosis and treatment. Thank you to everyone who participates in these discussions. We’re learning alot all the time and it helps to know that we’re not out there so alone.
Hi Percy,
I could have sworn I thanked you for this when you wrote it. I don’t see a comment from me, so I will thank you now. This had to have taken so much time and I am so thankful to have such a wonderful person to answer any question I may have. You are such a rare gem and I am so honored to know you. Thanks again for all you do.
-Pam
Thank you Percy.
This is extremely useful info for all of us.I would like to add that my husb has just been put on FOLFIRI and Cetuximab combo.
Also MD Anderson also seems to have advised Avastin and FOLFIRI although there aren’t any published reports on this.Lastly in surgey the Nano knife/IRE is in clinical trials at some places. My husb’ s case was non resectable and the IRE was used.
Thank you so much for the comprehensive list of treatments available. They will be most helpful in making our decision on what the next therapies should be after the chemoablation that my husband just had. I will bring this to the doctor on the next visit and we can discuss the options. I will keep you informed of the progress and hopefully that will continue for years to come.
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