The European Commission granted marketing authorization for the drug for the treatment of patients with hepatocellular carcinoma (HCC), the most common form of liver cancer in October 2007, [6], and approval Following the FDA for this indication in November 2007. [7]
In November 2009, the UK’s National Institute of Clinical Excellence Declined to approve the drug for use Within The NHS in England, Wales and Northern Ireland, Stating That ITS effectiveness (Increasing survival in primary liver cancer by 6 months) did not justify ITS high price , at up to