Hi,Marion,
Thanks for this info.,I will never have enough time to search everything and read everything;that is why everybody’s help is vital .Thanks again.
Our livers produce cholesterol and cholesterol produces bile acids to digest proteins and fatty acids in our small intestine .Statins are used to treat high cholesterol by inhibiting the synthesis of serum lipids and triglyceride.
In this study ,only the HYDROPHOBIC statins(atorvastatin-Lipitor,simvastatin-Zocor,lovastatin-Mevacor and pitavastatin-Livalo) can provide the added benefit of induce apotosis and inhibit proliferation in cholangiocarcinoma cells.Other statins like Pravachol,cerivsatatin are hydrophilic and will not have the same benefit.
The pre-treated cholangiocarcinoma cells with statins (in vitro) after 96 hours indicated that the future of inclusion of the statins in anticancer treatment regimens may reduce the amount of anticancer drugs used( such as 5FU,Gemzar and Cisplatin) and therefore the side effects that come along with them.
God bless.