The Cancer Genome Atlas – what does it mean for you?
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Foundation One is a a company that analyzes genomic profiles for cancer treatments. It identifies the molecular behavior of a specific cancer and may add the physician match the molecular profile with a targeted therapy (if available.)
Here is more:
http://foundationone.com/The Cancer Genome Atlas is US run program.
This describes the purpose of the TCGA:
The Cancer Genome Atlas (TCGA) began as a three-year pilot in 2006 with an investment of $50 million each from the National Cancer Institute (NCI) and National Human Genome Research Institute (NHGRI). The TCGA pilot project confirmed that an atlas of changes could be created for specific cancer types. It also showed that a national network of research and technology teams working on distinct but related projects could pool the results of their efforts, create an economy of scale and develop an infrastructure for making the data publicly accessible. Importantly, it proved that making the data freely available would enable researchers anywhere around the world to make and validate important discoveries. The success of the pilot led the National Institutes of Health to commit major resources to TCGA to collect and characterize more than 20 additional tumor types.
http://cancergenome.nih.gov/abouttcga/overviewGood info at the parent site:
with lots more references.
CCA is under Gastrointestinal as a disease under study. It appears that all data has been collected but the data is not publicly available.
Does anyone know if this is complementary to private sampling like FoundationOne or there is absolutely no connection and probably never will be?
Duke
All the DNA contained in your cells makes up your genome. In most cells, the genome is packaged into two sets of chromosomes: one set from your mother and one set from your father. These chromosomes are composed of six billion individual DNA letters. In the English alphabet there are 26 letters: A through Z. In the alphabet of our genes there are four letters: A, C, G and T. Just like the letters in a book make words to tell a story, so do the letters in our genomes. Genomics is the study of the sequence of these letters in your DNA and how each string of letters passes information to help each cell in your body work properly.
In cancer cells, small changes in the genetic letters can change what a genomic word or sentence means. A changed letter can cause the cell to make a protein that doesn’t allow the cell to work as it should. These proteins can make cells grow quickly and cause damage to neighboring cells. By studying the cancer genome, scientists can discover what letter changes are causing a cell to become a cancer. The genome of a cancer cell can also be used to tell one type of cancer from another. In some cases, studying the genome in a cancer can help identify a subtype of cancer within that type, such as HER2+ breast cancer. Understanding the cancer genome may also help a doctor select the best treatment for each patient.
◾Cancer Genomics: What Does It Mean for You?
http://cancergenome.nih.gov/PublishedContent/Files/pdfs/1.1.0_CancerGenomics_TCGA-Genomics-Brochure-508.pdf
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