The low down on my new chemo.

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  • April 11, 2012 at 1:22 am #59844
    pcl1029
    Member

    Hi,
    the Gemzar dose comes to 750mg/m2 but the duration of administration is >70 min. so basically you will have the same dose as before since the volume of distribution of Gemzar is a 2 compartment model. I will not worry about it since you are also on 2 other meds too.
    God bless.

    April 10, 2012 at 9:39 pm #59843
    tiff1496
    Member

    My body surface area is 1.77. I wonder if I need to ask about my gemzar dosage?

    April 10, 2012 at 8:05 pm #59842
    pcl1029
    Member

    Hi,

    The duration or dose does not affect overall clearance by the kidney.
    However the clearance of Gemzar is 31 % slower for women than men.
    For women,the half-life of the drug ranged from 50 min. for short infusions time(ie:30 min-1.2hr)) to 371 min for longer infusion.(ie: 1.2-5hr). Therefore the longer duration of administration of 75min. compare to the shorter 30 min.is really not that much difference except the Gemzar may be stay in your body a little bit longer than before. In such case ,I will drink more fluids to flush out the Gemzar out of my body .
    What is your body surface area? It seems the dose of gemzar is on the low side,but the Xeloda dose is on the 1000mg/m2 regular dose strength schedule.
    God bless.

    April 10, 2012 at 1:24 pm #59841
    tiff1496
    Member

    Thanks Lainy. I feel good about this new treatment.
    I’m feeling ok today, and about to take my Xeloda.

    April 10, 2012 at 2:53 am #59840
    lainy
    Spectator

    Good news, Tiff. Glad you feel so good and super glad you don’t need the neulasta!

    April 10, 2012 at 1:52 am #6643
    tiff1496
    Member

    So I got Gemzar for 75 minutes today. I will go next Monday and get another dose of Gemzar for 75 minutes. This is different for us because before I would only get it for 20-30 minutes. 1328mg each time.

    I will take 2000mg Xeloda twice a day for 14 days and then rest for 7 days.
    So a total of 4000mg a day. 8 pills.

    I’m also still on Traceva. 150mg a day.

    All of this is what Dr. Javle thinks I need. Any input on this?

    Thanks guys! And I feel really good today! And I don’t have to get my neulasta shot for right now. :)

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