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V3-X therapeutic vaccine

Discussion Board Forums Clinical Trials V3-X therapeutic vaccine

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  • #99377
    bglass
    Moderator

    Hi Stevieandme,

    There is not much recent information publicly available on the development of V3-X.  I looked at ClinicalTrials.gov and that info does suggest the trial is still ongoing.

    If a reader has a question for a specific discussion board colleague, it can be sent via the board’s message function which will notify the individual by email that someone on the discussion board has sent a message.

    Regards, Mary

    #99360
    Stevieandme
    Participant

    <p style=”text-align: right;”>Hi Riley</p>
    Just wondering how are things going, this med seems very interesting.

    I hope you can reply.

     

    Thank you

    #96831
    Riley
    Participant

    Hi Mary,

    I will keep you updated if we make any progress.

    My mother in law had a large tumor removed from her liver during July 2016. She had two cisplatin treatments, but then decided not to continue with treatment, as it was palliative and not curative.

    Yes, the trial is using very simple methods to evaluate response of the treatment. We are fortunate though to have access to MRIs etc and will make use of it.

    Regards,

    Jason

    #96830
    bglass
    Moderator

    Hi Riley,

    Thank you for this information and please let us know your mother-in-law’s experience with this drug under development.  Had she tried other treatments before this?

    I had read the study you reference and what had stuck in my mind was the fact that the patient outcomes were measured using tumor marker blood tests rather than the more usual measurement of tumor size (for growth or shrinkage).  The report states the researchers only have scans for a few patients because most of the trial participants did not have the economic means to pay for scans.  I guess this illustrates the challenges faced by researchers in lower-income countries in conducting clinical trials.  In the U.S. as well, patients lacking good insurance may face financial obstacles to participating in some clinical trials.

    This is a hopeful time for cholangiocarcinoma patients, with so many new treatments under development.  I hope your mother-in-law continues to feel better.

    Regards, Mary

     

    #96828
    Riley
    Participant

    Hi Positivity,

    V3-X is a therapeutic vaccine (not for prevention bu to treat). The company developing this had very good results on another product they developed (they actually by accident discovered its beneficial effects on liver cancer when treating Hepatitis patients) for liver cancer.

    Here is more info on the success they had with liver cancer:

    https://www.dovepress.com/open-label-phase-ii-clinical-trial-in-75-patients-with-advanced-hepato-peer-reviewed-article-JHC

    #96827
    Riley
    Participant

    Hi Mary,

    Thank you for your reply. Yes, the therapeutic vaccine for HCC is known as Hepko V5. The Study Director for this trial, Dr.  Bourinbaiar send us the V3-X as well as Hepkto V5.

    It seems that Dr. Bourinbaiar treated some CCA patients and got about a 50% response using the Hepko V5 vaccine. (although theoretically it should not be of much benefit to CCA patients). The same methodology was followed in creating the V3-X vaccine – using heat and chemically inactivated blood from CCA patients.

    My mother in law has been using the Hepko V5/V3-X combination for a little under 3 weeks. Her White Blood Count has come down from 18 000 to 7 000. Some inflammation markers also came down. She says that she has less abdominal pain and sleeps better. She does however still feel weak and sleeps a lot.

    The V3-X trial uses the reduction in the CA19.9 marker to determine if the tumor burden is decreasing or not. We will do the test probably in a week’s time and if an improvement go for MRIs.

    Regards,

    Jason

    #96825
    bglass
    Moderator

    Hi Riley,

    Thank you for your note and welcome to the discussion board.  I am sorry to learn that your mother-in-law was diagnosed with this cancer, and hope that the resources of the Cholangiocarcinoma Foundation website are helpful as you navigate the medical maze.

    There was a small flurry of news about the company and this new drug in development when the trial was announced, but the geographic location of the trial is so distant and there is less information floating around on this one relative to other current trials with sites in major U.S. hospitals.  The company according to its press information is developing a similar therapy for Hepatocellular Carcinoma, the more common liver cancer, which goes by V5-X, which seems farther along and already has some reporting out of clinical trial results in medical literature.

    To my best recollection, no one yet has posted on this discussion board who is participating in the V3-X trial.  Hopefully your message will attract response by a participant(s).

    I hope your mother-in-law is doing well and has found a skilled team of medical providers.  Please keep us posted on how she is faring.

    Regards, Mary

    #96821
    positivity
    Participant

    Interesting that this is a vaccine.  I have never heard of it, obviously since it is a trial.  Let us know how effective it is.  Did you ask the researcher if there were any other studies or how other patients are doing in the trial, unless it just started.

    #96811
    Riley
    Participant
    #96810
    Riley
    Participant

    Has anyone used V3-X therapeutic vaccine from Immunitor? The vaccine is currently used in a trial in Mongolia. Immunitor graciously send us the V3-X vaccine to treat my mother in law who has intrahepatic cholangiocarcinoma

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