We highly sugget patients have their tumor tissue undergo comprehensive testing for DNA alterations (faults) with the hope that a targeted agent may be useful. Unlike other cancers, cholangiocarcinoma does not yet have an approved targeted drug, hence patients must enroll in a clinical trial to investitigate efficacy of their very own tumor expression. This is called Personalized Medicine.
This site explains in detail the intricacies of targeted medicine. Enjoy
http://www.cancer.net/navigating-cancer-care/how-cancer-treated/personalized-and-targeted-therapies/understanding-targeted-therapy
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Marion