December 16, 2019 at 6:16 pm #99441
Thank you for sharing this good news that your results so far show stability. There is a lot of interest in our community about this and other new drugs on the horizon that bring us more and, hopefully, better treatment options.
Fingers crossed that good results continue.
Regards, MaryDecember 16, 2019 at 6:08 am #99438
Well, it’s still early, but decent results so far. I had my first “on trial” scan on December 2, and reviewed the results with Dr. Akce, my Emory oncologist and the PI for this trial at Emory, on December 5. The tumor had earlier been measured as 2.6 x 1.6 cm. In this scan it was reported at 2.8 x 1.8 cm, within the limits to conclude no progression and for me to remain on the trial. Dr. Akce also noted that it has been very difficult to precisely measure this tumor and there was a pretty good chance it really hasn’t grown at all. There has been no spread, and I have had really no side effects from the trial drug.
I will have my next scan at the end of January.
FredDecember 15, 2019 at 11:55 am #99437LitvakParticipant
maybe the results regarding the effectiveness of YELIVA are in?
– MBOctober 20, 2019 at 4:39 pm #99189
Thank you for the update, and congratulations on starting this trial. Fingers crossed the trial med brings you great results!
Take care, regards, MaryOctober 19, 2019 at 11:16 am #99187
Well, I finally started on this trial a bit over two weeks ago. So far no real side effects to report. I won’t get much of an idea about the effectiveness until my next scan in late November. I’ll keep this thread updated.
FredJuly 14, 2019 at 12:56 pm #98863
Thank you for your note. I looked through the discussion board and while there is discussion about possibly seeking this treatment, I did not find any patients who wrote about being treated with Yeliva. I also contacted a caregiver who was looking into it, and that patient did not in the end pursue Yeliva either. Hopefully, if a patient or caregiver who is under Yeliva treatment sees this string, they will post on their experience.
If you do enroll in this trial, I hope you will keep us posted.
Regards, MaryJuly 12, 2019 at 4:27 pm #98857
I may be going on this now Phase II trial. I’ll be meeting with Emory’s chief investigator on the trial within two weeks. Anyone have any more recent experience with this? Thanks.
FredMarch 21, 2016 at 5:41 pm #91945
Thanks Gavin – that’s all great infoMarch 19, 2016 at 1:13 pm #91941gavinModerator
Welcome to the site. Here is another page with some links on Yeliva for you. Hope that they are of use and interest to you and I look forward to hearing more from you.
GavinMarch 18, 2016 at 3:16 am #91944marionsModerator
A bit more, Mike….. Angiogenesis plays a critical role in the growth and spread of cancer. A blood supply is necessary for tumors to grow beyond a few millimeters in size. Tumors can cause this blood supply to form by giving off chemical signals that stimulate angiogenesis. Tumors can also stimulate nearby normal cells to produce angiogenesis signaling molecules. The resulting new blood vessels “feed” growing tumors with oxygen and nutrients, allowing the cancer cells to invade nearby tissue, to move throughout the body, and to form new colonies of cancer cells, called metastases.
Because tumors cannot grow beyond a certain size or spread without a blood supply, scientists are trying to find ways to block tumor angiogenesis. They are studying natural and synthetic angiogenesis inhibitors, also called antiangiogenic agents, with the idea that these molecules will prevent or slow the growth of cancer.
MarionMarch 18, 2016 at 3:00 am #91943
Thanks so much Marion:
Another article out yesterday. Was Mayo the Phase I? Interesting that it was ‘non-clinical’…
I understood that it was an inhibitor – but some hope in the this statement
“The Mayo researchers, along with Dr. Smith and others, concluded that Yeliva’s targeting of SK2 in the affected cells inhibited cancer proliferation and induced apoptosis – or self-destruction – in the cholangiocarcinoma cells.”
thx! Mike BMarch 18, 2016 at 12:48 am #91942marionsModerator
mikeb…..hello and welcome to our group. I don’t think they set a date for a phase II study as of yet, but it will take some time i.e. months or more.
As far as I understand it, SK2, is an angiogenesis inhibitor, which inhibits the growth of blood vessels. It does not necessarily kill tumors but instead may prevent tumors from growing. It is not a targeted agent and does not require molecular testing.
MarionMarch 17, 2016 at 11:15 pm #12295
I recently saw this press release for YELIVA – ABC294640 – which is focused on Cholangiocarcinoma.
Does anyone know if/when a Trial will take place?
It looks like they have tried initial trial for Lymphoma. Does anyone know any feedback on this trial?
It seems focused on Sphingosine kinase-2 (SK2) inhibitor. I’m not sure if this is important inhibitor in all Cholangiocarcinoma cases, or if only in sub-set with specific markers?
Thanks to anyone with info mb
- You must be logged in to reply to this topic.