Your thoughts on Cyberknife vs GammaKnife vs Proton Therapy vs TARE/SIRT?

There has been much debate but few actual studies comparing EBRT methods like Cyberknife vs GammaKnife vs Proton Therapy and also TARE/SIRT methods for unresectable Intrahepatic CCA. What have been your experiencies with them? Would be great to read some thoughts 🙂

We are not that much interested on OS actual studies but shrinkage/apoptosis capability/rate instead…

My 78y mother is new to Intrahepatic CCA (non resectable at time of diagnosis 2 months ago). Was identified by chance while scanning for something else. It’s a 6-7cm moderately diffuse mass that started at the bile duct. No stage/code has been given to us. No external symptoms whatsoever (no pain/jaundice/etc). Normal blood/liver panel.

She was put on GemCis treatment right after it, now going cycle 3 out of 6. Inmune system holding up quite good, first post-chemo CT scans coming in a few days so crossing fingers for some partial shrinkage.

We are hoping for some shrinkage for possible radiofrequency ablation/Cyberknife/SIRT treatment.

I live in London but she lives in Argentina – I’ve been in contact with Cyberknife centres in Chile, Brazil and Spain. Also with a Proton Therapy centre in California. They all have advised us to wait for the first 3 CHEMO cycles and post CT scan in order to evaluate possible radiation treatments.

Together we can beat it!

Luis