My mother died of cholangiocarcinoma in 1985 at the age of 50. My older sister died of cholangiocarcinoma in 2005 at the age of 50. We do not have familial polyposis. I am 58 and had a negative MRI when I was 50 with a repeat negative at 53. I just got some routine blood work back that shows elevated ALT and alkaline phosphatase. Of course I jump to the worst conclusion! I wish I had blood samples from my mom and sister for this project.