chrisa
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I believe that there is no study that points to Cholangiocarcinoma being a familial cancer. Like all cancer, cholangiocarcinoma is a genetic disease, but should not be confused with hereditary disease.
For example:
Inheritance of mutant tumor suppressor genes explain many familial cancers, however, mutant proto-oncogenes are seldomly transmitted through the germ line.So, for a study to conclude that cholangiocarcinoma is hereditary, the investigators would need to identify the genes responsible for the disease. Family history studies, in my opinion, are of little value as it is difficult to disentangle environmental factors (since most families live together). So much more work needs to be conducted on CC!
Referring to a previous post in this thread, I find it strange that any doctor would order tests on a child of a CC patient based on hereditary concerns alone. There are no screening tests for CC that I am aware of, and the tumors are notoriously difficult to image. Surely, the child was presenting with something more than his heritage!
I write this in hope that your mind be put at ease. Your question is one we all think about, but today there is nothing telling us that we should worry.
With warm regards,
ChrisLet me guess… Your husband’s prescription was for Zofran. My understanding is that insurance often objects to paying for this expensive drug. My wife was initially rejected by the prescription plan. However, under the insistence of my employer’s HR manager and the doctor, the insurance company paid for all but 5% of the cost. The process took a few days…
I am sorry to hear report of your husband’s low appetite and that the cancer seems to be more active. My warm wishes are with you and sincere hope that the chemotherapy quickly improves your husbands situation!
Warm Regards,
Chris
