Ltt2018

Thanks! That was exactly what I needed. I found a paper from 2014 that cites the paper you linked and corroborates the existence of a radiographically-detectable “flare response” that bone metastases may exhibit in response to successful chemo treatment.

Bone health in cancer patients: ESMO Clinical Practice Guidelines by R. Coleman published in 2014

“The use of bone scanning for assessment of response to therapy has always been contentious, and is certainly unreliable when lytic metastases predominate. After successful therapy for metastatic disease, the healing processes of new bone formation cause an initial increase in tracer uptake (akin to callus formation), and scans carried out during this phase are likely to show increased intensity and number of hot spots. After treatment for 6 months, the bone scan appearances might improve, as the increased production of immature new bone ceases and isotope uptake gradually falls. This ‘deterioration’ followed by subsequent ‘improvement’ in the bone scan appearances after successful therapy has been termed flare response.”