After receiving my diagnosis of recurrent ICC with resection not an option, my oncologist started treatment with gem/cis/durvalumab. We were able to get through two cycles and had to pause because of my creatinine levels getting too high and my platelets too low. My oncologist is concerned that the durvalumab might be adding to the side effects that the gem/cis are causing. Our plan was to do four cycles of gem/cis/durvalumab and scan and then continue on for six months or so with only durvalumab. We might have to go the targeted therapy route since I have the BRAF mutation after finishing my fourth cycle. I’m wondering if anyone has had any success with this course or my sane situation. Freaking out in Florida!!!