My sister was given Opdivo when her tumors continued to grow on Oxaplatin & 5FU. It was off label and the company gave it at no charge. She had three treatments of it but the tumor continued to grow. Initially we thought that it would take 2-3 months for it to start working but a scan was done after the third infusion and the tumors were still growing. Apparently they can tell if the growth is being affected by the drug. It was stopped and she is now on irinotican.