Biliary Tract Cancer Cell Lines & PDX Resources

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These cell lines are available under MTA’s from the designated repositories.  Please click on the links in the right column for contact information of each repository and specific instructions for requesting cell lines.

NAME Cell line or PDX SOURCE DESCRIPTION LINK or contact person
EGI-1 DSMZ (ACC-385) EHCCA https://www.dsmz.de/catalogues/details/culture/ACC-385.html?tx_dsmzresources_pi5%5BreturnPid%5D=192
HuCCT1 JCRB (JCRB0425) IHCCA http://cellbank.nibiohn.go.jp/legacy/celldata/jcrb0425.htm
KKU-100 JCRB (JCRB1568) Human poorly differentiated cholangiocarcinoma cell line established from biliary tract. http://cellbank.nibiohn.go.jp/~cellbank/en/search_res_det.cgi?ID=7096
KKU-M214/M213 JCRB (JCRB1557)/(JCRB1556) IHCCA http://cellbank.nibiohn.go.jp/~cellbank/en/search_res_det.cgi?ID=7076
MMNK-1 JCRB (JCRB1554) Highly differentiated immortalized human cholangiocyte cell line (non-cancer) http://cellbank.nibiohn.go.jp/~cellbank/en/search_res_det.cgi?RNO=JCRB1554
OZ JCRB; JCRB1032 IHCCA (Derived from metastatic site: Ascites) http://cellbank.nibiohn.go.jp/legacy/celldata/jcrb1032.htm
SNU-1079 KCLB (01079) IHCCA http://cellbank.snu.ac.kr/english/sub/catalog.php?s_cellid=91&page=detail_info&CatNo=59&strQ=01079
SNU-1196 KCLB (01196) EHCCA http://cellbank.snu.ac.kr/english/sub/catalog.php?s_cellid=162&page=detail_info&CatNo=59&strQ=01196
SNU-308 KCLB (00308) GBC http://cellbank.snu.ac.kr/english/sub/catalog.php?s_cellid=92&page=detail_info&CatNo=59&strQ=00308
SNU-478 KCLB (00478) BTC, ampulla of vater http://cellbank.snu.ac.kr/english/sub/catalog.php?s_cellid=95&page=detail_info&CatNo=59&strQ=00869
SNU-869 KCLB (00869) BTC, ampulla of vater http://cellbank.snu.ac.kr/english/sub/catalog.php?s_cellid=95&page=detail_info&CatNo=59&strQ=00869
RBE RCB (RCB1292) IHCCA http://www2.brc.riken.jp/lab/cell/detail.cgi?cell_no=RCB1292
SSP-25 RCB (RCB1293) IHCCA http://www2.brc.riken.jp/lab/cell/detail.cgi?cell_no=RCB1293
TFK-1 RCB (RCB2537) EHCCA http://www2.brc.riken.jp/cache/cell/RCB2537
TGBC1TKB RCB (RCB1129) GBC (Derived from metastatic site: Lymph node) http://www2.brc.riken.jp/lab/cell/detail.cgi?cell_no=RCB1129
TKKK RCB (RCB1907) IHCCA http://www2.brc.riken.jp/lab/cell/detail.cgi?cell_no=RCB1907
YSCCC RCB (RCB1549) IHCCA http://www2.brc.riken.jp/lab/cell/detail.cgi?cell_no=RCB1549
HuCCT1     Dr. Lawrence Kwong lkwong@mdanderson.org
OZ    
SNU-1079    
RBE    
SSP-25    
TKKK    
CC-LP-1    
CC-SW-1    
Huh-28    
SNU-245    
SNU-1196    
WITT    
TFK-1    
Koch     Dr. Sergio Gradilone sgradilo@umn.edu
Hucct-1    
H69    
Huh-28   IHCCA Dr. Giovanni Brandi giovanni.brandi@unibo.it 
Dr. Simona Tavolari simona.tavolari@unibo.it
TFK-1   EHCCA
SNU-245   EHCCA
SNU-1079   IHCCA
WITT   EHCCA
EGI1   EHCCA
H69   Immortalized cholangiocytes
HuCCT1     Dr. Vaibhav Sahai vsahai@med.umich.edu
TFK-1    
JCRB: Japanese Collection of Research Bioresources Cell Bank http://cellbank.nibiohn.go.jp/english/
DSMZ: Deutsche Sammlung von Mikroorganismen und Zellkulturen https://www.dsmz.de/
KCLB: Korean Cell Line Bank https://cellbank.snu.ac.kr/main/index.html
RCB RIKEN Cell Bank http://www2.brc.riken.jp/lab/cell/search.php
Cholangiocarcinoma cell lines Dr. Xin Wei Wang xw3u@nih.gov
Cholangiocarcinoma cell lines for Kras, SMAD4, P53, and ARID1A mutations Dr. Aram Herzel aram_hezel@URMC.rochester.edu
Cholangiocarcinoma cell lines and 30 human cholangiocarcinoma PDX models Dr. Gregory Gores gores.gregory@mayo.edu
Cholangiocarcinoma cell lines and cholangiocarcinoma PDX models Dr. Lewis Roberts Roberts.lewis@mayo.edu
Dr. Fowsiyo Ahmed ahmed.fowsiyo@mayo.edu
Cholangiocarcinoma PDX models Dr. Funda Meric-Bernstam fmeric@mdanderson.org
Cholangiocarcinoma PDX models Dr. Sergio Gradilone sgradilo@umn.edu
Cooperative Human Tissue Network (CHTN)* https://www.specimens.cancer.gov/details/283/?c2=224
Brain and Body Donation Program* https://www.specimens.cancer.gov/details/494/?c2=224
Gundersen Biobank* https://www.specimens.cancer.gov/details/207/?c2=224
Hollings Cancer Center Biorepository & Tissue Analysis Shared Resource* https://www.specimens.cancer.gov/details/357/?c2=224
NCI DTP DCTD Tumor Repository* https://www.specimens.cancer.gov/details/646/?c2=224
OHSU Knight BioLibrary* https://www.specimens.cancer.gov/details/295/?c2=224
Ontario Tumour Bank* https://www.specimens.cancer.gov/details/620/?c2=224
University of Iowa Tissue Procurement Core Facility* https://www.specimens.cancer.gov/details/293/?c2=224
 

These cell lines are available under MTA’s from the designated repositories.  Please click on the links in the right column for contact information of each repository and specific instructions for requesting cell lines.

We would like this resource to be comprehensive and widely available to those who are interested in research. It is our desire to provide interested researchers with as much validated information as we can to expand the collaborative CCA research community. If you are aware of available resources not listed, please contact us.

A number of human biliary tract cancer cell lines have been reported in the literature, including cell lines derived from intrahepatic cholangiocarcinoma, extrahepatic cholangiocarcinoma, and gall bladder cancer. The table lists commonly used biliary tract cell lines available from repositories. Also listed is an immortalized but non-transformed human bile duct-derived cell line.

If you have additional information about human biliary tract cancer cell lines, please contact info@cholangiocarcinoma.org

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Cholangiocarcinoma (CCA) Mutations

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CCAMutations
Visit the International Cholangiocarcinoma Research Network (ICRN)