Cholangiocarcinoma and the Cancer Genome Atlas (TCGA)
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Your donations at work with the Cancer Genome Atlas. Please see link:
http://servicetoamericamedals.org/honorees/view_profile.php?profile=423Hi Beverley,
Just want to join in with Marion and Lainy in welcoming you here. Sorry about your mum and your sister as well, that is far too much for one person to deal with is it not. Hope that you will post some more here on the site and I look forward to hopefully hearing more from you.
My best to you,
Gavin
Beverly…..you may want to consider participating in the GWAS study:
http://cholangiocarcinoma.org/professionals/action-alert-mayo-clinic-study/
Hugs,
MarionBeverly, I believe we as caregivers naturally get that “feeling” especially if 2 in a family have had CC. For years after my husband passed I always questioned if anything was the slightest off. I am sorry about your Mother and Sister as one in a family is too much! Try not to worry and enjoy life as your Mom and Sister would want you too.
berverly……thanks for chiming in. I think all of us touched by this cancer live in fear of contracting this disease as well. Although there have been some isolated cases of CCA occurrence within families, a genetic link has not been established. I assume that further testing will be done in your case.
Hugs,
MarionMy mother died of cholangiocarcinoma in 1985 at the age of 50. My older sister died of cholangiocarcinoma in 2005 at the age of 50. We do not have familial polyposis. I am 58 and had a negative MRI when I was 50 with a repeat negative at 53. I just got some routine blood work back that shows elevated ALT and alkaline phosphatase. Of course I jump to the worst conclusion! I wish I had blood samples from my mom and sister for this project.
So agree with you both, we have come a long way in these years have we not? But there is still lots and lots to do! As the saying goes, mighty oaks from little acorns grow and we will keep on growing!
Hugs to all,
Gavin
Oh, I so agree. This site began a couple of months after Teddy’s Whipple and I know it is normal to feel totally lost in the beginning of a diagnosis BUT we have come so far in the last 10 years!! We just need to keep the momentum going and hope and miracles help as well. Remember all diseases started out “not knowing” and we are already getting very well known which is half the battle. I know we will climb that mountain and some day CC will be a Cancer of the past! Than you to all of you who are working so diligently to achieve this monumental goal!
The most fantastic news is the attention given to our cancer; a far cry from what we experienced when your Dad or my husband had been diagnosed.
Hugs,
MarionThanks for this Marion, excellent news. Let’s keep things crossed that so much good will come from this.
Hugs,
Gavin
TCGA is a joint effort of the National Cancer Institute (NCI) and the National Human Genome Research Institute (NHGRI) Cancer aiming to advance personalized medicine through the DNA sequencing and analysis of patient tumors to find new genetic alterations associated with specific cancers.
http://cancergenome.nih.gov/Understanding the genetic changes that are in cancer cells is leading to more effective treatment strategies that are tailored to the genetic profile of each patient’s cancer.
Cholangiocarcinoma is on of 13 cancers selected in the Rare Cancer Project for comprehensive molecular analysis on multiple platforms, including whole exome sequencing, messenger RNA sequencing, micro RNA sequencing, whole genome copy number analysis, whole genome methylation analysis, and whole genome proteomic analysis.
http://cancergenome.nih.gov/cancersselected.Several academic centers provided the NCI with 54 samples however; only 39 of the 54 passed the more stringent RNA qualification criteria. The Cholangiocarcinoma Foundation submitted $26,720.04 for inclusion of the additional required 15 samples.
Hugs,
Marion
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