Search Results for 'gemcitabine cisplatin'
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Search Results
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Metformin potentiates the anticancer activities of gemcitabine and cisplatin against cholangiocarcinoma cells in vitro and in vivo.
In reply to: My Mum, 49yo in Australia
Hi everyone,
Mum had a follow up CT scan on Monday. Since last checking in Mum has not had any further treatment.
Today she saw her Oncologist, who said that there are no new mets (yay!), however the primary tumour has grown a few mm in size, which wasn’t the best news we wanted to hear given she had SIRT 5 months ago.
Unfortunately I was unable to attend the appointment, but mum asked about if she could have repeated SIRT treatment however her oncologist said she “already had a lifetime of radiation” and it wasn’t appropriate. I found this information conflicting given that there has been studies showing the safety profile of repeated SIRT treatments and there’s even people on these boards who have had repeated treatments also. So I have told mum to ask her oncologist (who will be calling her in the next few days) for a review by the doctor who performed the SIRT.
So the next step, as per the oncologist, is to discuss with the surgeon the possibility of microwave ablation on the primary tumour. I understand the tumour is very large so this will be difficult. The oncologist said if this isn’t possible she will be starting gemcitabine/cisplatin very shortly. I’m upset she has to return to chemo, but the side effect profile will be much better than the FOLFIRNOX she had last year. The irinotecan really took its toll on her.
As for immunotherapy, the trials available to her are apparently not showing any positive results vs chemo alone. Keytruda (Pembrolizumab) is still $$$ expensive and we cannot afford it.
Topic: New Caregiver
Finally got on to register with your sight and I’m so happy to be here! My husband was diagnosed on my birthday (July 9) and you can be sure that I won’t forget that birthday! After a week of stomach aches, he consented to be taken to the ER in the middle of the night. It was there that the ER doctor saw that he was jaundiced and suspected the bile duct blockage. (I thought he was just tan, as usual. I know, stupid!) Anyway, after four days in the hospital and multiple tests, he was scheduled for surgery two weeks later for a resection. We both realize how fortunate he was that it could be done! He was ten days in the hospital after the surgery and upon his return home, he suffered an extremely painful recovery. But lo and behold, two months after the surgery, he is doing well and has gained back half of the twenty five pounds that he lost. He is doing his 50 push ups and kettle bell routine every morning and feels wonderful. He just started chemo (gemcitabine/cisplatin) last week and has not had one bad side effect. We feel very blessed that it all has progressed so well but still worry constantly about what is to come. (That’s definitely me talking because I’m a professional worry wart.) Thus one of the reasons for my post: I want to be a good caregiver but not a “mothering, smothering” caregiver. I read this sight all the time as well as many articles as I can find on the subject of cc. Do I read too much, I ask?? My husband doesn’t read anything related to his disease at all, by the way. The question then becomes how much information do I tell him or not tell him? I know someone can give me their two cents (or more if so inclined.)
Study of DKN-01 and Gemcitabine/Cisplatin in Patients With Carcinoma to Primary to the Intra- or Extra-Hepatic Biliary System or Gallbladder
https://clinicaltrials.gov/ct2/show/NCT02375880
21 evaluable patients received a 300 mg regimen of DKN-01 plus chemo, 33% (n=7/21) were partial responders. Additionally, the disease control rate (partial responders + those with stable disease) was 95% (n=20/21). Median progression-free survival (PFS) and overall survival (OS) have yet to be reached.
The combination regimen was safe and well-tolerated with no reported serious adverse events or dose-limiting toxicities.DKN-01 is a humanized IgG4 monoclonal antibody that binds to Dickkopf-1 (DKK1), a protein associated with a poor prognosis in a range of cancers. Specifically, it inhibits a pathway called canonical Wnt/Beta-catenin which plays a key role in embryonic development, cell proliferation and differentiation.
Hi my name is Lisa from Australia and I am 51 years old. It has now been one year since my diagnosis of cholangiocarcinoma. After a routine laparoscopy I started intense Chemotherapy of Cisplatin and Gemcitabine. Initially I was told that surgery was not an option
I responded very well to 5 cycles of chemo and the cancer shrunk considerably enough to prompt my liver surgeon to operate. One month before the surgery I had a portal vein embolisation and on May 18 this year three quarters of my liver was removed. I recovered very well from this surgery. Pathology reports revealed an aggressive cancer and the need to continue chemo. I only had 3 infusions out of 6 with my body not responding to the drugs this time around. As a result the CT scan showed metastases to the lungs and parts of the newly regenerated liver. My oncologist has placed me on Xeloda – oral tablet chemo. I have just completed one cycle and started the 2nd cycle. I feel well physically and have not had any side effects from the medication.
Mentally I have lost some strength and positivity becausecI do not know where my illness will take me. I am scared. I feel very fortunate to have a supportive husband and strong network of family and friends.A pilot study of concurrent chemoradiotherapy with gemcitabine and cisplatin in patients with locally advanced biliary tract cancer.
In reply to: Introduction / Welcome
Thanks much. Here is additional information:
http://www.senhwabiosciences.com/senhwa-biosciences-initiates-phase-12-trial-of-cx-4945-in-combination-with-gemcitabine-and-cisplatin/http://www.evaluategroup.com/Universal/View.aspx?type=Story&id=603034
Hugs,
MarionIn reply to: Introduction / Welcome
Lynnette……welcome and congratulations on making the leap to internet engagement. You have made a great choice, dear Lynnette, in that this site is populated with the kindest, nicest, most helpful people I ever have encountered. First and foremost, congratulations on the spectacular results with treatment. Understandably you are concerned about the predictions of life expectations, but please keep in mind that no one can predict for sure the outcome of each individual, this includes specialists opinions as well. Hence try to focus on being around for a long time to come and await to benefit from newly developed treatment options. There are available and others are here to tell us about it.
Again, we are happy to see you on board and expect our conversations to continue for a long time to come. I am wondering, dear Lynnette, what is the name of the third agent added to Gemcitabine and Cisplatin?
Hugs,
MarionIn reply to: Introduction / Welcome
I am just joining the discussion board. My name is Lynette. I am 57 years old. Almost exactly a year ago I went in for laparoscopic surgery to have my gallbladder removed for supposed gallstones. When I awoke from anesthesia the surgeon explained that he had not completed the procedure because when he had gone in he had recognized he was seeing a tumor on my liver, so he took a tissue sample and pictures and got out. I was referred to an oncology surgeon who ordered more tests, and a week later he informed me the tumor was too large for me to be a candidate for surgery, and I was referred to an oncologist. The diagnosis was of cholangiocarcinoma; it was subsequently classified as intrahepatic. The oncologist confirmed that my cancer was unresectable, and was stage III into stage IV. He indicated that if I had no treatment, I had about six months to live, and that if I entered treatment, I had 12 to 18 months.
In retrospect I had probably been having some symptoms for nearly two years prior to my diagnosis; I had been having sharp pains shooting from my shoulder blades up to my neck, for which my GP had diagnosed a strong anti-inflammatory pain pill, which had been generally effective. I now understand this pain was most certainly referred pain from the liver area. I had only gone back to my GP last year because I was starting to have more heartburn issues. An ultrasound was done which was interpreted as indicating that I had many gallstones, bringing me to the laparoscopic surgery.
Anyway, after the dire prognosis of the oncologist, I sought and received a referral to Mayo Clinic in Rochester, MN. The gastro-oncologist there confirmed the diagnosis and the stage, but indicated there was a trial available that might be beneficial. I started that trial in late September 2015. I have standard chemo of Gemcitabine and Cisplatin on Wednesdays, and Tu., We., and Th. I take an oral trial chemo medication, all on a two week on, one week off schedule. My tumor has shrunk from a starting point of about 11 cm to about 2 cm.
Since June this year the tumor shrinkage has stopped but is stable. I should mention that there is one and maybe two peripheral tumors elsewhere on the liver, which are extremely small. The Mayo oncologist is positive yet, as there has been no growth. I confess that my expectations of a miracle may have been too large, so I am frustrated that the tumor is not simply disappearing. It appears that my best option is simply to continue the same chemo regimen, including the trial drug, as long as I am able. I am starting to have some neuropathy in my fingertips, however. My Mayo doc indicates that if the neuropathy becomes too significant, I could continue the regime minus the cisplatin.
Given the anniversary of my diagnosis, I have been doing more self-reflection and reexamination, including re-reviewing internet research. Nothing I read gives me much more positive perspective than my initial oncologist’s prognosis. Even my Mayo doc does not contradict that prognosis, even though a year’s gone by and my tumor has shrunk so much. As I look forward to the unknown, I’m doing something I’ve never done before by joining an internet discussion board. Not surprisingly I know no one else with this cancer, and don’t believe those with other cancers can really relate to what we are dealing with. So I am looking forward to sharing experiences with others who are in the same or more similar position to myself.
In reply to: Gem/Cis – Weighing Options
Your Mom has valid concerns.
This link will lead you to the outcome of the ABC-3 study: Cisplatin plus Gemcitabine
http://www.nejm.org/doi/full/10.1056/nejmoa0908721#t=article
Ultimately it comes down to making a decision of unknown outcome and although no one can predict how your Mom will fair with treatment, she does however have the opportunity to withdraw at any time. Buying time is important, we don’t know what other available options await us. There is the risk of reducing quality of life, but how do we know unless we try?
I know that your Mom will make the right decision.Hugs,
MarionTopic: Keytruda
My wife was diagnosed with Hilar CC last November. She had 4 infusions of gemcitabine and cisplatin. She then had radiation 5 days a week for 5 weeks along with 5FU administered 24/7 using a fanny pack. This did not shrink tumor (it has remained mostly unchanged) that is involved with the arterial blood supply enough that the surgeon would recommend resection.
On 8/10/16 she had her first infusion of Keytruda. She experienced no side effect until the 5th day when she had some general joint pain along with some mild intermitting right lower stomach pain. For the last couple days she has had mild persistent back pain in the region of her kidneys.
I am posting this an example of one patients early response to Keytruda and also to ask others to share their experience with this drug.
In reply to: Hi – new to the site. Just likely diagnosed with IHC
Hi Marion and All,
Here is what I have found out regarding the available clinical trial:It is Phase II
It is to study coplanlisib (BAY 80-6946) in combination with gemcitabine and cisplatin in advanced cholaniocarcinoma.
The Protocol Number is MCC# 18436
Moffitt Cancer Center is the sponsoring hospital and Dr. Richard Kim is the Study Doctor
Quick Summary: Coplanilsib is an experimental/investigational medication that blocks the enzyme Phospho-Inositol-3-Kinase (PI3K) that is normally important for the growth of tumor cells
Any thoughts?
In reply to: Hi – new to the site. Just likely diagnosed with IHC
The tumor board at Moffitt Cancer Center in Tampa has asked if Barb would like to be part of a clinical trial. In addition to the std chemo drugs of gemcitabine and cisplatin, they are combining a third chemo drug.
Note – Barb has ‘too many masses to count’ in her liver so chemo is the option.
Any thoughts on being part of a clinical trial?My mother was 61 years old. She has hilar cholangiocarcinoma. The pathology from operation is T2a, N1 and adjuvant chemotherapy was suggested. We visited the doctor this Wednesday. The doctor told us that my mother should receive chemotherapy within 6-8 weeks after the operation. He recommended us to use intra-arterial infusion chemotherapy. He would put an artificial vessel over celiac trunk artery, so the chemo-drug can infuse directly to the tumor region. The treatment would be 6 cycle(once per 3 weeks) with 3 combined drugs(gemcitabine, cisplatin, 5-FU). He told us that the regimen can acheive 40-50% control rate. He would also start the immuno-cellular therapy at the same time(stimulate the patient’s T cell by her own dendritic cell which has interacted with cancer cell first , then proliferate the antigen specific T cells and re-infuse them from the artery). The T cells should be injected in the period of 7 days before and after chemotherapy, or else the T cells would be killed by the chemo-drug.
Now, I’m quite worry about the side effect of chemo-drug, since 3 kinds of drug was used at the same time. Could anyone share your chemo-experience?? Actually, we are still hesitate whether to receive the chemotherapy or not. Because my mother has been very weak after the operation(She is quite good before the surgery). It has been 4 weeks after the surgery. However, fever is still noted. The doctor said that recurrent cholangitis is inevitable due to reconstruction of bile duct with intestine.
We’re also seeking for nutrition therapy. Do anyone have any information to this?? Thankyou very much:)Topic: STARTRK-2
Hi All,
Does anyone gone through STARTRK-2 RXDX-101 and if so, how did it go?
I’m 58 years old, live with my wife in Hawaii and was diagnosed with intrahepatic cholangiocarcinoma in February of 2015 by a 6 cm tumor in the right lobe of my liver. Resection surgery in March 2015 (at Queens Medical Center in Hawaii) removed the tumor, followed by 12 cycles of cisplatin and gemcitabine which took six months. Two months later another tumor was found adjacent to the location of the previous tumor. This second tumor was removed (at MSKCC in NYC) on March 23 of this year and now I have a small tumor in each lung that has grown from 2 mm to 5 mm in two months. Requested for but have not had mutation testing done on either of my removed tumors. My CA19_9 is 9 (it was 108 for the original tumor and 7 for the second tumor) and CEA is 3.4 (it was 2 for the original tumor and I’m not sure what it was for the second tumor).
Looking for a phase 2 clinic trial however they are saying that my current tumors are to small, it needs to be at least 10 mm or 1 cm.
V/r,
Layne
