Search Results for 'gemcitabine cisplatin'

Key messages

Cholangiocarcinoma is anatomically classified as intrahepatic, perihilar, and distal
Mixed hepatocellular-cholangiocellular carcinoma is a subtype of intrahepatic neoplasm that shows markers of hepatocellular carcinoma and cholangiocarcinoma differentiation simultaneously and is associated with worse prognosis compared with hepatocellular carcinoma
Cirrhosis and hepatitis B and C are recently identified risk factors for intrahepatic cholangiocarcinoma
All intrahepatic lesions in cirrhosis should be investigated to rule out the possibility of intrahepatic cholangiocarcinoma
Fluorescence in-situ hybridisation improves performance of cytological evaluation of biliary brushings for the diagnosis of perihilar cholangiocarcinoma
Proliferative and inflammatory gene signature classes have been described in intrahepatic cholangiocarcinoma; FGFR2 gene fusion and IDH1 and IDH2 mutations are newly identified targetable derangements in cholangiocarcinoma
Surgical resection is a first-line therapy in patients with intrahepatic or perihilar cholangiocarcinoma who are good surgical candidates and have no evidence of disease progression beyond regional lymph nodes
Surgical techniques for perihilar cholangiocarcinoma are improved by extended resection, portal vein embolisation, and associating liver partition and portal vein ligation for staged hepatectomy
The best outcomes are observed in highly selected patients with perihilar cholangiocarcinoma treated with liver transplantation coupled with neoadjuvant chemoradiation
Locoregional therapies can be considered for intrahepatic cholangiocarcinoma
Gemcitabine and cisplatin combination is an acceptable standard of practice for advanced intrahepatic cholangiocarcinoma; for perihilar disease the effectiveness remains less proven
Elucidation of cholangiocarcinoma molecular pathogenesis could guide early diagnosis, prevention, and individualised treatment

Read text here:
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4069226/

This is my first post, though I’m not newly diagnosed. I’m glad you’re here!

After diagnosis of intrahepatic CC in September 2014 — in both lobes of my liver, not a candidate for surgery or radiation I was told — I was on gemcitabine until mid-August (first with cisplatin then with capecitabine). I did great — lots of tumor shrinkage, pain decreased, labs good, side effects not too bad. But my August CT showed the tumors growing again and now there are a few small mets in my lungs.

My oncologist is looking into next treatment options, as am I. I am soon going to Mayo Clinic for a consult.

Last September, it was an easy decision to go with gemcitabine; that seemed to be the consensus among the experts I checked with at the time. Now it’s not so clear what the “best” second line is. Apologies if this has been discussed already; there are so many posts that I am not sure where to start looking for answers to my question. Or if this is too wide open a question.

I’m also wondering if I should focus on a clinical trial at this time.

Anyone have any advice? Thanks!

Hello all
After many months of having elevated liver enzymes I was diagnosed on April 2nd 2014 with extrahepatic hilar CC. I was told it was an early detection and I was eligible for the liver resection surgery. After getting a second opinion from Sloan I returned to Cincinnati and had my surgery at UC Medical on April 10th. The surgery was successful at getting the entire tumor along with 70% of my liver and 9 clear lymph nodes. Margins were also clear but some very slim (1mm). The cancer was stage 2 and the cells were graded “well differentiated”. I was also told the nerve was involved and that might be a good reason to get Chemotherapy treatments. Do any of you know what exactly the ramifications of nerve involvement are or could be? I did follow up with 6 Chemo treatments of cisplatin & gemcitabine and 6 of gemcitabine only. Took a 4 week break followed by 5 weeks/25 radiation therapy with 5FU treatments. I was able to take the 5FU for only half way through because of low platlettes. I figured since I was relatively young (57) with no other health problems and a strong desire to live I would leave it all on the field as they say. All treatments concluded mid December and my CT scans in January and April of 2015 were NED. I have since been doing just about every Integrative therapy I can find, definitely over the top. Next scan will be in October.
Thanks for listening and I pray you all have a long and happy life.
Greg

Cediranib or placebo in combination with cisplatin and gemcitabine chemotherapy for patients with advanced biliary tract cancer (ABC-03): a randomised phase 2 trial.

http://www.ncbi.nlm.nih.gov/pubmed/26179201

90Y Transarterial Radioembolization (TARE) Plus Gemcitabine and Cisplatin in Unresectable Intrahepatic Cholangiocarcinoma.

https://clinicaltrials.gov/ct2/show/NCT02512692

Adjuvant Chemotherapy With Gemcitabine and Cisplatin Compared to Observation After Curative Intent Resection of Biliary Tract Cancer (ACTICCA-1)

https://www.clinicaltrials.gov/ct2/show/NCT02170090?term=NCT02170090&rank=1

Hi,

The only woman I have ever loved and married was recently diagnosed with Cholangiocarcinoma.
Carol is 73 and was in better shape mentally and physically than most 50 year olds I know.
In the late 60’s early 70’s Carol had exploratory surgery to find a malformed bile duct. This was corrected and while she had up and down liver values most of her life, she was in good health. In 2013 Carol started to have issues with her liver values again, had two different stents placed to take the pressure off of her bile duct from a cyst on her pancreas. Lahey Clinic Burlington MA performed a Whipple removing the head of the pancreas, rerouting her small intestines and cutting down her bile duct. No cancer found??

June 2015 she starting feeling bad, was Jaundiced, light headed bloated. Dartmouth Hitchcock did a CAT scan, MRI, and PET scan, each one telling something worse. They put in a stent, then a metal stent as the first was not working. The metal stent is somewhat working and on August 6th she starts Chemo at Dana Farber in Boston. Reading how poisonous some of these drugs are make me wonder if it is worth it. She is starting on gemcitabine and cisplatin. She has several cancerous tumors 12.5mm, 6.?mm and lesions on her liver, undiagnosed at her operation 1.5 years ago. Told it is advanced and no other options will work for her.

She really wants to go to Ireland and I am wondering if she will ever feel good enough to go. She is not at present, and I only wonder how this Chemo will affect her and if we are on a slippery slope downward from here.

I guess I just had to do a brain dump. Every one of our friends has offered to help, but I just do not know how they can.

Thanks for listening

Steve

This study added cediranib a VEGF inhibitor to gem/cis/
The combination of Cediranib/Gem/Cis did not improve progression free survival over treatment with Gem/Cis.
Cediranib Versus Placebo Plus Cisplatin/Gemcitabine Chemotherapy for Patients With Advanced Biliary Tract Cancers (ABC-03)
https://clinicaltrials.gov/ct2/show/NCT00939848

Marion

ABC-2 study results:
Gemcitabine With or Without Cisplatin in Treating Patients With Unresectable Locally Advanced or Metastatic Cholangiocarcinoma or Other Biliary Tract Tumors (ABC-02)
https://clinicaltrials.gov/show/NCT00262769

The combination of Gemcitabine/Cisplatin significantly increased survival rate.