Search Results for 'gemcitabine cisplatin'

Hi my name is Sherri and I’m 54 and was diagnosed in December with CCA. Had surgery in January to removed tumor and get a new bile duct and 2 lymnoids came back bad. Started chemo of cisplatin and gemcitabine in February. Had 4 treatments just to be told yesterday it wasn’t working. Spots on scan and tumor markers doubled. I have contact MD Anderson Cancer Center to see if they will take me. Is there any hope with this cancer? I feel so lost right now and just want somewhere to go that someone will keep trying.

Gemcitabine, Cisplatin, and Abraxane in Advanced Biliary Cancers.

https://clinicaltrials.gov/ct2/show/NCT02392637

Hi all,

What is the likelihood, in your experience, of an initial three-month (2 weeks on / 3 weeks off) course of Gemcitabine/Cisplatin completely removing a 1cm-wide metastatic liver lesion in an advanced stage distal cholangiocarcinoma patient?

Or put another way, if a CT scan after three months supposedly showed the above, would you be surprised? If so, would you seek a second opinion and/or MRI (either as a patient or oncologist)?

Thanks.

Have not written in the discussion forum since my wife’s diagnosis. I do hope that eveyone is well and still “fighting the fight” against this horrible disease. Since Oct. when we found out about this my wife has been through 3 sessions of chemotherapy (carboplatinum /cisplatin/Gemcitabine) and a full round of Y90. These therapies have not produced the results that our team has wanted.
She recently was put on Afinitor (oral) due to certain tumor markers that have been discovered. Our oncologist, who we believe in 100% has suggested that she go back on chemo for the next 12 weeks (4 sessions total)…Cisplatin/Gemstar along with the Afinitor.

I guess my question is as follows: Has anyone been on this type of protocol before? and has it been sucessful to enhance the Afinitor as we have been told? My initital understanding was that systemic chemo struggles against this type of tumor and I would hate to see her go through the difficult side-effects that she experienced before. Believe me, this is not a “give-up” just a question to reach out to this amazing group of people for some insight.

All my best (as always!) Jim

Hi Everyone,

Sadly my mum (49) was diagnosed with CC in early December 2014 after numerous endoscopy scans etc. after severe stomach pains and jaundice. Her surgeon said her tumour was distal to the bile ducts and in a position for The Whipple Procedure. This was scheduled for January 2015. Her surgeon was confident about the removal of the tumour and informed us all she would need no chemo and just to concentrate on the recovery of such a massive operation.
The last few weeks have been really hard as you all know, along with watching my mum recover we were all anxiously waiting on the results from her surgery.
So last Tuesday her surgeon told us that it wasn’t quite what they had hoped, that the tumour was 0.9 mm near major blood vessels and cancer cells were present in 8 of 25 removed Lymph nodes. Her next option was chemotherapy to prolong her life, and that she was to live her life and gave her a prognosis of approx. 2 years to live. The next two days were a living hell for my poor mum and my family. Then on Thursday she had an appointment with her oncologist who explained things a little bit better (well a little). He went onto explain that they do think there were microscopic cells left behind and that this treatment of Gemcitabine and Cisplatin CAN kill these microscopic cells off. That he wasn’t giving her palliative chemo but she was high risk. It’s all a little confusing. I asked what happens after the cycle of chemotherapy and how we test her cancer cells etc. to check for Mets. We were told after the cycle of chemo then that’s it. No other testing and the next stage would be symptomatic.
Does anybody else have a similar story and can maybe offer me and my family some advice.
Feeling very sad, confused and lost .

Love to you all x

Hello everyone,

I am new to this board. My family is based in metropolitan Australia. My relative is 72 years old and has just been diagnosed with a 9.9cm solitary intrahepatic cholangiocarcinoma. The tumour originated in the right lobe of the liver, but has pushed into the left lobe and is close to the portal vein (we don’t know if it has invaded the portal vein or not), making immediate operation difficult. Her liver function tests are slightly elevated, but she has no hepatitis or cirrhosis. Her tumour markers were all normal. CT chest / abdo / pelvis suggest no macroscopic spread outside of the liver. She has no other significant medical conditions.

The surgeon and oncologist – who both operate out of a major teaching / tertiary referral hospital – have recommended neoadjuvant systemic chemotherapy (gemcitabine plus cisplatin). They believe surgery will be possible with a 20% reduction in the tumour. My relative had her first dose of chemo a few days ago. She will have a follow-up CT abdo after 2 cycles (ie. in about 6 weeks’ time) to determine whether the cholangiocarcinoma can be surgically removed.

We were told that liver transplantation is not a viable option, as cholangiocarcinoma can often have microscopic spread beyond the liver. Once a transplant is in place, the immunosuppression required would allow any distal cancer cells to grow out of control.

I have a few questions:
1. Do you know of liver transplantation in similar situations, ie. with a large, solitary intrahepatic cholangiocarcinoma and no macroscopic spread beyond the liver?

2. How important is it to seek a second opinion, either here or overseas? There isn’t really a culture of doing this in Australia, and we are wary of offending the original doctors, who we respect a great deal. But could a different surgeon perhaps operate, even if a 20% reduction in tumour size isn’t achieved with chemo?

3. How important is it to get molecular testing done on the tumour tissue? We were told that this is not routinely done in Australia.

Thanks in advance for your help!

Adjuvant chemotherapy with gemcitabine and cisplatin compared to observation after curative intent resection of cholangiocarcinoma and muscle invasive gallbladder carcinoma (ACTICCA-1 trial)

https://www.clinicaltrialsregister.eu/ctr-search/search?query=eudract_number:2012-005078-70

I was diagnosed in May 2014 with stage 4 cholangiocarcinoma. I went for an annual check up and my liver enzyme count was elevated. I have a large tumor in my liver and several nodes on my lungs. I have been on gemcitabine and cisplatin since late May. I have no physical symptoms. I’ve tolerated chemo well until I recently began having ringing in my left ear. My oncologist reduced the cisplatin. Thankfully I’ve got a wonderful support system and many people praying for me. I’m convinced that I will survive this crazy diagnosis. I get fatigued for a few days after treatment and that’s it. I have a great team of doctors and feel fortunate. My large tumor has gotten smaller on each of the CT scans I’ve had to date. Some of the lung nodes have also gotten smaller. I have been genome tested and a FGFR2 gene mutation has been found. There are currently clinical trials for this mutation. Since I’m doing well, I actually don’t qualify for the trial, but if things should change, it’s confiorting to know I have another option to survive this cancer. I’ve read some of the posts on the discussion boards and find them very interesting and many of them encouraging.