Search Results for 'gemcitabine cisplatin'

Mayo clinic is conducting a research study in conjunction with Bayer.

The study involves taking BAY 80-6946 (Phosphatidylinositol-3 Kinase Inhibitor) in combination with Gemcitabine OR Cisplatin plus Gemcitabine.

Joanie may be a candidate for this study. We are wondering if anyone else is a part of this study and your experience.

Thank You

My husband is the patient. It started in January 2013 with jaundice. An endoscopic retrograde cholangiopancreatography was performed, and a plastic stent was inserted. The stent opened the bile duct and the jaundice gradually subsided. In February he had a CT scan of the pancreas. The scan was not conclusive for a pancreas diagnosis.
A consult with the team at Seattle Cancer Care Alliance was conducted. Their diagnosis is Cholangiocarcinoma of the bile duct. The team surgeon said there was no surgical option. The team medical oncologist said my husband’s options are: do nothing or do chemo. He recommended that the plastic stent be replaced with a metal one. [It has since been replaced with another plastic one.]
Further tests were conducted by SCCA: chest xray, an ultrasound and a liver biopsy. Review of these tests by the medical oncologist and the results are the same: do nothing or do chemo. The chemo recommended is Gemcitabine and Cisplatin.
We would be grateful to hear any opinions and suggestions. Thank you so much for your time.
Iris

A Phase I/II Dose Escalation Study to Assess the Safety, Tolerability and Efficacy of Amphinex-induced Photochemical Internalisation (PCI) of Gemcitabine followed by Gemcitabine/Cisplatin Chemother…

https://www.clinicaltrialsregister.eu/ctr-search/search?query=eudract_number:2012-002888-10

Dear members,

It has been a while since I posted. My mom was diagnosed with cholangiocarcinoma spread throughout the liver and lymphe node in June 2012 and started in July with Gemcitabine/Cisplatinum. She just finished 8 rounds of chemo without major complications. She had an enourmous drop of CA19.9 from over 140.000 to 158. her scan in October showed shrinkage of all tumours. Her scan results from January just came in and showed shrinkage BUT 3 new spots appeared. 2 in the liver and 1 in her upper right lung. This was not at all what we had expected since the CA19.9 was decreasing and she was just feeling better and better. Since the tumour broke through the chemo it has become useless and there is not much that he can do for us right now, the doctor said. There is an scan appoinment in April to how the new spots grow. All documents have been sent to an other clinic to hear their view on this case. For now it feels just so frustrating that we cannot do anything to fight this cancer.

Is there anyone with some good advice or recommendations that we can follow?

thank you very much and stay strong.

Jorrit

Hello All

I am so pleased and relieved that I have found this site!

After my diagnosis last month I have had a whirlwind of activity, but finding a consistent and informative source of information seemed impossible – until now.

I am 55 years old in March, married with two grown-up step-daughters and also our 10 year old daughter at home. I run an IT Operations function for one of the major UK cultural Public Sector institutions, and I am being treated at St James’ Hospital, Leeds, West Yorkshire in the UK.

The “high” [ironic] points thus far:

Since 2010 I had experienced acute reflux 3-4 times per year, my GP had diagnosed it as such and treated me for this. I had put the cause down as in part stress-related.

In September, 2012 however, I had the same symptoms coupled with vomiting, agonising pain in my upper right chest and a high fever which lasted until 0400 the next morning. I made an appointment to see my GP the next day, as when I looked in the mirror I was obviously also jaundiced (I have not had these symptoms since).

My GP gave me a letter and instructed me to travel to the local hospital and get admitted for an ultrasound scan, as he suspected an escaped gallstone. I arrived at the hospital in early afternoon and was seen by the Registrar at 1830 (in between I had an IV drip inserted and a notice was posted above my bed stating “Nil by Mouth” around 5 minutes before a hot lunch was served to everyone but me ).

The Registrar was of the opinion that the gallstone had already begun travelling out of my body, and offered to admit me to hospital that night for an ultrasound the next day (although being a Sunday he was doubtful), or alternatively having one the next week as an out-patient; I chose the second one and went home to dinner. My discharge letter from the hospital noted “deranged LFTs” and “bilirubin down 161 to 43” – whatever that means.

My ultrasound occurred in early October, and I then received an appointment for three days later with a consultant colorectal surgeon. He opened the conversation by looking at my record on his computer system and telling me I hadn’t had a scan. I replied I had, I then spent 30 minutes waiting for the scan results to be found and added to the system; I was then informed that the results were being faxed through, the consultant would review them and send me a letter containing the outcome later that day.

I received the letter a week later (the consultant had indeed written up his findings that day, however it had taken his secretary a further 5 days to type the letter). The day before I received an appointment for a CT scan which baffled me until the next day, when the consultant’s letter explained.

The letter confirmed that I had gallstones and said that the bile duct, spleen, pancreas and kidneys appeared normal, however stated that there was an “abnormal area” on my liver that the radiologist suggested needed a CT (CAT) scan. The letter also said that in due course an MRI scan of my bile ducts might be needed. I had my CT scan a week later, and a week after that received a letter from the consultant which said “The CT scan performed recently to investigate the liver lesion seen on your ultrasound scan suggests that this is fat deposited within the liver. However we would like to perform a further scan called an MRI to investigate this….no other abnormalities were seen other than a fatty lump within the transverse colon. The pancreas was normal”.

The MRI scan was run in the middle of November, and I then received an appointment to see the same consultant as before on 12th December, 2012; I had concluded that, whatever the underlying problem was, it wasn’t critical because of the gap between the scan and the appointment. Imagine therefore my surprise when I was ushered in to see the consultant, and he introduced me to a MacMillan Nurse. He explained that “sadly” he would have to refer me to a specialist in Leeds, as the MRI scan showed an abnormality in my liver which had the appearance of “a cancer arising in the liver, or possibly arising in the bile ducts within the liver”. The consultant said that the specialists in Leeds would determine the best treatment option.

From here on in things moved with some haste. My wife and I met with an Hepato-Pancreato-Biliary (HPB) Surgeon at Leeds St James on 17th December, 2012. He explained that my scans showed the presence of a “large likely intrahepatic cholangiocarcinoma involving completely his IVC as well as both left and right portal veins. Although the left hepatic is patent, the fact that the tunour extends across to the umbilical fissure makes him at this stage unsuitable for an R0 resection (complete resection) of his tumour” (the quotes above and below are from the letter from the consultant to my GP, which I requested and received a copy of).

I asked what my prognosis was after chemotherapy, which is what the surgeon recommended, and he said anywhere from 6 to 18 months, however he stressed also that there are a number of variable factors, and that a lot depends on the outcome of the chemotherapy. We asked if surgery might be re-considered post-chemotherapy if it were successful in shrinking the tumour, and he agreed (his letter confirms this part of the conversation but adds “…..although in my opinion it is extremely unlikely”). He also recommended a liver biopsy and a PET Scan before seeing an Oncologist, and I was assigned a Specialist Nurse as my single point of contact.

My wife and I decided we would focus on having the best family Christmas and New Year ever before telling them, and that’s just what we did.

I had the biopsy on 23rd December, 2012, (and felt my existence “stutter” just after they pushed the button…..), then the PET Scan on 28th December, and then finally an another appointment with the HPB Surgeon on 21st January, 2013 – at which stage I rang my Specialist Nurse and she arranged an Oncologist appointment for 11th January, 2013 (see, I’m beginning to learn).

The Oncologist said that the PET Scan confirmed an intrahepatic cholangiocarcinoma of 15cm in size, that it had not metastasised elsewhere, and recommended a 12-week programme of gemcitabine and cisplatin chemotherapy (four 3 week cycles, chemo Week1 and 2, Week3 a rest week), followed by another PET Scan. We agreed, and I’m at the end of Week3 of the first cycle. She also said she viewed the chemotherapy as active rather than passive (palliative).

I guess some of my comments above could come across as derogatory to the medical profession, however this is absolutely not the case. For most of my life I’ve been ridiculously healthy (if increasingly unfit). Every nurse and doctor I have met has been clearly professional, interested and caring in their approach, even though they are under sustained pressure of work. If I had one constructive criticism it is that some of the administrative and workflow processes seem unnecessarily prolonged or are missing. (a 20 page A4 booklet for admission to hospital which needs to be filled in by a Nurse then checked by the ward sister, then at various stages other documents which need to be filled in and which ask the same questions again?)

I’m lucky in that I have few chemotherapy side effects thus far, namely insomnia (=get more exercise during the day), inflamed knuckles on both hands (=aqueous cream), slight abdominal discomfort rather than pain (=lots of little chemo elves cutting away at that pesky tumour).

Latest news is that my tumour marker (CA19.9) score on 24th January was 529, down from 624 on 17th December, however I’m told they look for a trend across the full chemotherapy cycle. Still, a good start.

I’ve initially taken four months of extended sick leave from work, we met with a MacMillan advisor who applied successfully on my behalf for Disability Living Allowance, (terminally ill patients qualify – meaning <6 months to live by their definition), and also had help from MacMillan Financial Advice (piloted in Yorkshire since 2011), and also with the local Hospice specialists (I had always imagined Hospice services were solely deployed at the end of an illness, but was delighted to learn they offer a range of counselling and complementary therapy services).

I’ve also begun to put financial affairs in order, so that my wife and children have as financially stable a situation as possible, and, of course, I’ll need to make a will.

I stop smoking tomorrow (I started when I was 11), I’ve joined a gym to build up core body strength, and I’ve totally changed my diet to more or less exclude all meat save fish and the odd piece of chicken (lentil shepherd’s pie anyone?), I tell myself I love Brussel sprouts and all forms of vegetables and fruit – and it must be working because I feel great.

The lessons I have learned thus far from this unlooked for experience are:

1. It’s OK to cry. When something so shattering happens it’s all right to cry. It’s a human reaction and it will make you feel better. It is also OK to curl up in a ball in the corner for a while and attempt to deny the undeniable – just so long as it doesn’t become a permanent condition, because after that you have stuff to do.

2. It is also OK to get angry – so long as you channel that anger into productive activity.

3. Own your condition. Patients should not be passive, but should actively pursue understanding of their condition and of treatment options, and should build relationships with and interact with carers on a basis of mutual respect.

4. Make a list of all the things you ever wanted to do and, while you are still able, get as many of them done as possible (including finally fixing that yard gate).

5. Confound expectations – make a plan. We have just celebrated our daughter’s tenth birthday. I will bend my every effort to be there for her next one.

6. When you are told you need to be admitted to hospital and you have a choice between a local one which is close or a regional centre which is further away, choose the latter every time.

Apologies for the ramble. Future posts will be short and to the point. I am so pleased and relieved to have found this fantastic resource.

I have some questions on the above and welcome all opinions and advice.

1. I’ve read a number of forum posts which advocate getting second opinions on treatment approach. Should I seek a second opinion on whether surgery is an option, and if so should I do this ASAP or await the outcome of the chemotherapy? (I saw a reference elsewhere in the forum to Professor Peter Lodge)

If the chemotherapy is unsuccessful would I still have options for a Whipple or a liver transplant?

Best Regards
Jim

Hi,
Here are the agents and regimens that are under development or review for cholangiocarcinoma . enjoy.

vandetanib – Drug Profile 47
Im-01 – Drug Profile 49
ARRY-162 – Drug Profile 51
Triphendiol – Drug Profile 53
elpamotide – Drug Profile 54
Gemcitabine + Cisplatin – Drug Profile 55
chloroquine – Drug Profile 56
erlotinib hydrochloride – Drug Profile 57
Gemcitabine + Oxaliplatin + Erlotinib – Drug Profile 59
Oxaliplatin + Erlotinib + Gemcitabine – Drug Profile 61
Irinotecan + Oxaliplatin – Drug Profile 63
Capecitabine + Epirubicin + Carboplatin – Drug Profile 64
Gemcitabine + Radiation Therapy – Drug Profile 66
stakel – Drug Profile 68
gemcitabine – Drug Profile 69
sorafenib tosylate – Drug Profile 70
Panitumumab + Gemcitabine + Oxaliplatin – Drug Profile 71
sunitinib malate – Drug Profile 73
capecitabine – Drug Profile 74
selumetinib sulfate – Drug Profile 75
temoporfin – Drug Profile 76
Gemcitabine + Capecitabine – Drug Profile 77
Erlotinib + Gemcitabine + Oxaliplatin – Drug Profile 78
Lapatinib – Drug Profile 80
Bevacizumab + Erlotinib Hydrochloride – Drug Profile 81
Gemcitabine + Cisplatin – Drug Profile 83
dolastatin 10 – Drug Profile 84
Capecitabine + Gemcitabine + Radiation Therapy – Drug Profile 85
trastuzumab – Drug Profile 87
Gemcitabine + Capecitabine – Drug Profile 88
Gemcitabine + Oxaliplatin + Sorafenib – Drug Profile 89
Zactima + Gemzar – Drug Profile 90
Tumor Infiltrating Lymphocytes + Cyclophosphamide + Fludarabine + Aldesleukin – Drug Profile 92
Gemcitabine + Cisplatin + Sorafenib – Drug Profile 94
Gemcitabine + 5-Fluorouracil + Radiation Therapy – Drug Profile 95
Gemcitabine + Cisplatin + S-1 – Drug Profile 97
gemcitabine – Drug Profile 99
Gemcitabine + Sorafenib – Drug Profile 100
S-1 + Photodynamic Therapy – Drug Profile 101
S-1 + Cisplatin – Drug Profile 102
Gemcitabine + Irinotecan + Panitumumab – Drug Profile 104
Oxaliplatin + Capecitabine + Sorafinib – Drug Profile 105
gemcitabine – Drug Profile 106
Gemzar + Taxotere – Drug Profile 107
Eloxatin + Xeloda – Drug Profile 108
Gemcitabine + Docetaxel + 5-Fluorouracil + Radiation Therapy – Drug Profile 109
Bevacizumab + Erlotinib – Drug Profile 111
S-1 + Gemcitabine – Drug Profile 112
Cancer Specific Antigen-Derived Peptide Vaccine + Gemcitabine – Drug Profile 113
Gemcitabine + Cisplatinnn – Drug Profile 114
fluorouracil – Drug Profile 116
TS-1 + Gemcitabine – Drug Profile 117
Capecitabine + Oxaliplatin – Drug Profile 118
everolimus – Drug Profile 119
Gemcitabine + Oxaliplatin + Capecitabine – Drug Profile 120
GEMOX – Drug Profile 121
Gemcitabine + Cisplatin – Drug Profile 122
HLA-A 2402 Restricted A2691N Peptide + D0006 Peptide + F2861 Peptide + Montanide ISA-51 – Drug Profile 123
Gemcitabine + Radiation Therapy – Drug Profile 124
Gemcitabine + Cisplatin – Drug Profile 125
Gemcitabine + Cisplatin – Drug Profile 126
tegafur + gimeracil + oteracil potassium – Drug Profile 127
tegafur + gimeracil + oteracil potassium – Drug Profile 128
Gemcitabine + Radiation Therapy – Drug Profile 129
gemcitabine – Drug Profile 130
Irinotecan + Gemcitabine – Drug Profile 131
Gemcitabine + TS-1 – Drug Profile 132
Gemcitabine + Cisplatin – Drug Profile 133
cisplatin – Drug Profile 134
Epirubicin + Carboplatin + Capecitabine – Drug Profile 135
mFOLFOX – Drug Profile 137
Gemox – Drug Profile 138
UFT + Leucovorin – Drug Profile 139
Gemcitabine + S-1 – Drug Profile 141
gemcitabine – Drug Profile 142
Glivec + 5-Fluorouracil + Leucovorin – Drug Profile 143
Fludarabine + Cyclophosphamide + CD8+ Enriched TIL + Aldesleukin – Drug Profile 144
Gecitabine + Cisplatin + S-1 – Drug Profile 146
SOX – Drug Profile 148
gemcitabine – Drug Profile 149
Gemcitabine + Oxaliplatin + Capecitabine + Bevacizumab – Drug Profile 150
Gemcitabine + Oxaliplatin + Capecitabine + Panitumumab – Drug Profile 152
5-Fluorouracil + Leucovorin + Oxaliplatin – Drug Profile 154
Cisplatin + Fluorouracil + Radiation Therapy – Drug Profile 156
Gemcitabine + TS-1 – Drug Profile 157
Gemcitabine + Capecitabine – Drug Profile 158
Gemcitabine + Oxaliplatin – Drug Profile 160
porfimer sodium – Drug Profile 161
Gemcitabine – Drug Profile 162
Cetuximab + Gemcitabine + Oxaliplatin – Drug Profile 163
Modified FOLFOX6 + AZD2171 – Drug Profile 164
Docetaxel + Oxaliplatin – Drug Profile 166
Cisplatin + Gemcitabine + Selumetinib – Drug Profile 167
KB-9520 – Drug Profile 168
gemcitabine – Drug Profile 169
S-1 + Oxaliplatin – Drug Profile 170
gemcitabine – Drug Profile 172
tegafur + gimeracil + oteracil potassium – Drug Profile 173
ABT-888 + Cisplatin + Gemcitabine Hydrochloride – Drug Profile 174
GEMOX + Cetuximab – Drug Profile 176
Cisplatin + Gemcitabine + Panitumumab – Drug Profile 178
Gemcitabine + Cisplatin + S-1 – Drug Profile 179
Gemcitabine + Cisplatin – Drug Profile 180
Gemcitabine + Cisplatin + Carboplatin + Capecitabine + 5-Fluorouracil + Radiation Therapy – Drug Profile 181
Gemox 85 – Drug Profile 183
Oxaliplatin + Gemcitabine + Radiation Therapy – Drug Profile 184
WT1 Peptide Vaccination + Gemcitabine + Cisplatin – Drug Profile 185
FOLFOXIRI – Drug Profile 186
Gemcitabine + Cisplatin + S-1 – Drug Profile 188
Gemcitabine + S-1 – Drug Profile 190
gemcitabine – Drug Profile 191
imatinib mesylate – Drug Profile 192
ProLindac + Gemcitabine – Drug Profile 194
Cisplatin + 5-Fluorouracil + Gemcitabine – Drug Profile 195
JP-1584 – Drug Profile 197

God bless.

Hi All~~

God’s blessings to you all.

My husband was diagnosed with a CC Distal Tumor in 2010. He had a Whipple in Indianapolis. Small tumor: Stage 1b…clean, no invasions, negative (but very close) margins. Due to margin being a little closer than surgeon’s comfort level, my husband followed up in Goshen with radonc (5FU) and chemotherapy regimen of gemcitabine/cisplatin. His return to the new ‘normal’ has been gradual but, overall, pretty great. We’ve counted our blessings each step of the way. He finally began feeling well this past July. Running, gardening, hunting. Still, continual GI pains: burning, guts so active, some pain/cramping. It’s intermittent. Doesn’t seem to be related to certain types of foods, when he eats, how much, etc. He takes Creon three times a day. Recent pain has developed while lying on back…stomach pain that sort of radiates to back. Occasional.

He graduated to 6-month follow-up CT scans (at least he was supposed to.) The September scan in Inday was great. Surgeon was pleased with all. A little continued inflammation at connection site, but otherwise good. Then, in March, went to Goshen for blood work. His medical onc called and said his CA 19-9 and CEA were elevated. 3X what they were in September. Unexplained. No physical symptoms. He had a CT. Nothing too remarkable…except 2 4mm spots on right lung. Onc was not overly concerned about those…new CT machine (very sensitive) and they may have been there all along. Certainly not enough to explain spike in tumor marker. He met with his peer group and they decided to do a endoscopy on Monday. Look around the bile duct area. They were all generally perplexed about the rapid elevation…with no physical symptoms and a clear looking CT. Our doctor told us it’s possible they won’t see a thing on the scope. They don’t initiate a new treatment plan based on tumor markers alone (not that we want them to.) So…

This is where we’re at. I, of course, tend to become gripped with fear at each possibility. I wish it wasn’t so. I am up and down. My husband is all about: no need to panic….we need more information. He’s right. God is in control. One day at a time. This is the new normal. Wish I could plant myself there and let it go?!! I have caught myself trying to really overly control other aspects of daily life…of course because this area is so outside of my control. How do you all manage these up and down emotions?

Also, what does chronic pancreatitis look like? I’ve wondered if this might be the cause of his ongoing pains? And, even more so now that it radiates to his back and he occasionally feels flu-ish. The oncologist does not think this ongoing gastric upset has anything to do with spiked tumor markers at this stage….would have happened some time ago. My husband has been a 2-3 glass of wine per night person…and, if we have something stronger, he will partake. I’ve asked him to cease all alcohol…he has. I’ve wondered if that has contributed to pains and/or increased markers?

What are your experiences?

Thanks for reading and caring. My best to all of you. You are all in my prayers daily….along with my Jon.

Blessings,
Laurie

Hi All~~

God’s blessings to you all.

My husband was diagnosed with a CC Distal Tumor in 2010. He had a Whipple in Indianapolis. Small tumor: Stage 1b…clean, no invasions, negative (but very close) margins. Due to margin being a little closer than surgeon’s comfort level, my husband followed up in Goshen with radonc (5FU) and chemotherapy regimen of gemcitabine/cisplatin. His return to the new ‘normal’ has been gradual but, overall, pretty great. We’ve counted our blessings each step of the way. He finally began feeling well this past July. Running, gardening, hunting. Still, continual GI pains: burning, guts so active, some pain/cramping. It’s intermittent. Doesn’t seem to be related to certain types of foods, when he eats, how much, etc. He takes Creon three times a day. Recent pain has developed while lying on back…stomach pain that sort of radiates to back. Occasional.

He graduated to 6-month follow-up CT scans (at least he was supposed to.) The September scan in Inday was great. Surgeon was pleased with all. A little continued inflammation at connection site, but otherwise good. Then, in March, went to Goshen for blood work. His medical onc called and said his CA 19-9 and CEA were elevated. 3X what they were in September. Unexplained. No physical symptoms. He had a CT. Nothing too remarkable…except 2 4mm spots on right lung. Onc was not overly concerned about those…new CT machine (very sensitive) and they may have been there all along. Certainly not enough to explain spike in tumor marker. He met with his peer group and they decided to do a endoscopy on Monday. Look around the bile duct area. They were all generally perplexed about the rapid elevation…with no physical symptoms and a clear looking CT. Our doctor told us it’s possible they won’t see a thing on the scope. They don’t initiate a new treatment plan based on tumor markers alone (not that we want them to.) So…

This is where we’re at. I, of course, tend to become gripped with fear at each possibility. I wish it wasn’t so. I am up and down. My husband is all about: no need to panic….we need more information. He’s right. God is in control. One day at a time. This is the new normal. Wish I could plant myself there and let it go?!! I have caught myself trying to really overly control other aspects of daily life…of course because this area is so outside of my control. How do you all manage these up and down emotions?

Also, what does chronic pancreatitis look like? I’ve wondered if this might be the cause of his ongoing pains? And, even more so now that it radiates to his back and he occasionally feels flu-ish. The oncologist does not think this ongoing gastric upset has anything to do with spiked tumor markers at this stage….would have happened some time ago. My husband has been a 2-3 glass of wine per night person…and, if we have something stronger, he will partake. I’ve asked him to cease all alcohol…he has. I’ve wondered if that has contributed to pains and/or increased markers?

What are your experiences?

Thanks for reading and caring. My best to all of you. You are all in my prayers daily….along with my Jon.

Blessings,
Laurie