Agios to Present Clinical Data from Ongoing AG-120 Phase 1 Trial

Here is the long awaited data from the ongoing Phase I A-G 120 trial for IDH-1 advanced patients who previously had been treated with one or more therapies.

There is no further enrollment for the dose escalation and expansion cohort, but those enrolled in Phase 1 will continue to be assessed for safetey and tolerability.

Stable disease was observed in 56% of patients
Partial response was observed in 5% of patients

Hugs
Marion

I realize I wasn’t super clear. So trial was over a few months ago, so they kept her on ag120 since she was responded. Back in January she went from shrinkage to stable , last week she went from stable to growth. She is now visiting friends in Colorado and will start keytruda once they schedule all of that. All these treatments all seem to be , could shrink then not. Could go remission , or could do nothing.

Thanks for the kindness here

Wife out of trial. On to keytruda sounds like.

Seems like that was 2 weeks of constipation pain She changed meds to mirilax and changed her diet and seems back to pre pain levels or energy. Or a little less

Thanks marions. Thag helps and makes stable sound more positive. Though this last week wife has new abdominal pain. She went back on oxy and that doesn’t seem to help. Waiting to hear back from her doctor when the work week starts. Went to er last night to make sure it want anything else and they couldn’t find anything and sent her home.

The only positive spin was her cousin was just in the hospital with severe abdominal pain and heh called it a virus and sent him home. Hopefully that’s it cause we saw him a few days after he felt better.

Well wife had her first scan in oct , shrinkage , scan in nov also had shrinkage. She didn’t tell me about The scan in dec . She wasn’t feeling as good last week which I attributed to not eating properly. Well latest scan has shrinkage and growth but over all stable whatever that means. She does get to stay on the trial which I think is good overall but seems like back to the roller coaster. I guess sometimes this works sometimes it doesn’t and sometimes it stops working ?

Dan,

So sorry for your loss. You and your family have my deepest sympathy.

Darla

Thank you to all of you for your kind thoughts and prayers. She passed away peacefully late last night with me and my sister resting on her shoulders. We are directing donations to the Dana-Farber cholangiocarcinoma research fund with the hope that perhaps it can be of help to someone in the future.

This forum has been very helpful to me. As a physician, I actually thought I would not get anything out of an internet forum about medical stuff. I was very wrong. Thank you to all of you for being there for my family.