An interesting publication about liver flukes
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Karen –
It’s always good to know someone from the area. Yes, we did flood in ’96 then again really bad again in ’07 and ’08. Most of Centralia had water in it. Also flooded bad out toward the coast. It was strange to see no traffic on the freeway.Even in nursing school I found the reason for cancer interesting….of course it’s a lot more personal now. I remember I statistic from nursing school that said that something like 50% of all people seen in a Level 1 trauma center develop cancer within 5 years….I don’t know if that was the exact stat but it was something that struck me as too high.
I know my husband comes from a family that cancer is rampant. His mother has had lung, colon, uterine, bladder and skin cancer…..yes all primary and she is still 70 years old and kicking. His maternal grandfather died from prostate cancer with mets to the brain and his uncle died from what he thinks was some sort of bone cancer. Plus Mark has had the lymphoma and now the cc. They lives “Down wind and down water” from an apple orchard converted to a gold course……do you think there might be a link? I do.
KrisV
Lainy, you’re welcome! Kris, thank you for your comments. Yes, inflammation is known to cause many issues in our bodies, including cancer! Very fascinating, complicated, and worrisome.
By the way, Marion gave me the heads up that as of last year, the genome for a particular liver fluke was discovered.
http://www.nature.com/ncomms/2014/140709/ncomms5378/metrics/news
Oh, and Kris, I noticed you are from Chehalis! I lived in and around that area for quite a long time. Wasn’t it the Skookumchuck and Chehalis rivers that flooded so badly back in what, 1996?
-Karen
There is a general belief that certain cancers….maybe all cancers are caused by chronic irritation and inflammation. Look at smokers and their increased risks of certain cancers or people who drink with increased cancers…..the list can go on and on. Now if we could just find the common point for people with. The problem though is the liver deals with all the toxins in our bodies where they are supposed to be there or not and trying to limit it to the one “cause” other than the ones we know of…..liver flukes, PSC and things like hepatitis.
KrisV
Karen, thanks so much for that article. I just sent it out to the family. I KNOW Teddy got his CC in Korea. Everything fits and when I read the part of the Ampulla Vater that really hit home as that is exactly where his was. I for one am a big believer in not eating Sushi as we really do not know where it all comes from. I just know and feel that Teddy would have eaten anything interesting back then especially fish!
Thanks for that Karen. THis is from AMMF in the UK re Liver Flukes and CC and it may be of interst to you.
http://www.ammf.org.uk/article-6-cc-in-thailand/?doing_wp_cron=1421868191.2284710407257080078125
My best to you,
Gavin
This is a paper out of Korea that I had not seen before, with more discussion about liver flukes, (a known causal agent of CC) chronic inflammation, and the high incidence of Cholangiocarcinoma related to this chronic inflammation in Southeast Asia.
“These facts suggest that clonorchiasis induced chronic persistent inflammation may develop to cholangiocarcinoma, and probably through step-wise evolution via precancerous stages”. (Lim, 2011).
Clonorchiasis sinesis is one type of liver fluke.
What I think is very important to note, is that there is an irritant (the liver flukes and it’s eggs, with subsequent bile duct irritation) and the author states that this “chronic persistent inflammation” can cause CC due to cellular changes. In fact, he states they are “step-wise” which to me would suggest that there is a pattern. Maybe from low grade dysplasia or cellular changes that are not too different from the normal cell, on through to severe dysplasia (many abnormal cells) to cancer.
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3088844/
Now I just want to know what causes the inflammation in people WITHOUT liver flukes, PSC, and other diseases, such as with my mother in law. Also, how to catch the precancerous, low grade dysplastic changes which must surely be present, and remove the cells before cancer develops.
-Karen
Please understand that this is only my opinion and not intended as fact. Always consult with your physician if you have questions or concerns regarding your medical condition.
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