ARQ-087 Clinical Trial : FGFR2 Tyrosine Kinase Inhibitor

Oh, Kris, stupendous news about no cancer sighting!!! I am over the moon for you. You are such a good model for hope and miracles. My wish is for everything to continue in the right direction and wish for good news about the eyes! I just want it all to come together in the best way cause you sure deserve a great break!

Hi, JD! Good news about your DH and hope for his ‘no side effects’ to continue. Good road you are on and here is wishing for the road to be smooth with no bumps! Good going!

My DH did indeed start this trial, last week. Six days of the pills so far, and no obvious side effects yet.

Yes, he had his CT scans done this morning. And tomorrow he’s getting a Zometa infusion to strengthen his bones (okayed by the trial team, even though he hasn’t started the trial yet).

We are still in his washout period, so at least right now we aren’t feeling like his care is being alarmingly delayed.

We also saw a different oncologist yesterday, for a 2nd opinion, at Georgetown, who agrees that at this stage, particularly given how good Bill still feels, that clinical trials are the way to go. I must say that it is becoming much more of a common refrain from oncologists that “chemo really doesn’t get you very far” with cholangio. They are all about the clinical trials, as many of them as you can daisy-chain together.

Hi Marion–Yes, he’s starting to feel some pressure under his rib cage again.

It looks like my husband will be starting this trial in November, if biopsy bureaucratic issues can get handled to get him set up without too much delay past his four-week washout date. (We are pretty sure his lesions are growing, so this makes for a sort of tense waiting period.)

We had looked at the NCI MATCH AZD 4547 FGFR inhibitor trial, which is close to home, but I wasn’t all that impressed with the numbers they had reported in the Phase 1 trials. Driving to Philly isn’t optimal, but isn’t the end of the world, either.

(This ARQ trial is now a Phase 2 trial for intrahepatic cholangio patients with an FGFR2 fusion.)

I was using boost in my smoothies but it’s pretty high in phosphates. And since my phosphates are high, it got cut out.
I think of you, too. I hope you’re doing well.

Well… Results of scan #2 on the trial. Mostly stable or minimal shrinkage. Nancy of you know this part… It seems I gave small nodules on my lungs and my kidney. Too small to determine anything at this point, so that’s hopeful. But they were there last scan and not reported! Ugh! I hate lazy radiologists. I know many gave had nodules for years, but it was still a bit of a heart stopper for me.
I am still on the trial. My phosphates are getting lower, but still high. My blood counts were low, esp. WBC, which was extremely low. But my onc said she’s willing to wait and see…
Overall a positive report, I think. Major side effects are lots of reactions to foods, esp fruit for some reason. So my main source of nutrition has become an issue….