January 31, 2013 at 8:09 am #68700marionsModerator
Sweetgreen….Phase I clinical trials are used to show that a new treatment is safe for a small group of people.
Phase II clinical trials provide more information about the safety of the new treatment and how well it works to treat cancer.
Phase III clinical trials compare the new treatment with the standard treatment in a large group of people.
MarionJanuary 30, 2013 at 5:15 pm #68699sweetgreenMember
This sounds interesting! How do you know if you should be in a Phase 1 or Phase 2 trial? Maybe I should send this to my husband’s oncologist.
Here’s the link to the one at Wake Forest: http://www.clinicaltrials.gov/ct2/show/NCT01766219?term=cholangiocarcinoma&cntry1=NA%3AUS&state1=NA%3AUS%3ANC&rank=4January 29, 2013 at 8:36 am #68698marionsModerator
Tracey….agree. This is a tough cancer to diagnose and to treat, but we have seen some incredible responses from numerous patients; no reason to believe that for your Dad not to be part of the fortunate group. BTW: I could only find a phase I trial and assume that your Dad is being offered a Phase II at Wake.
Please, keep us posted. Fingers are crossed and tons of good wishes are heading your way.
MarionJanuary 29, 2013 at 12:40 am #68697tschildren7Member
Pam-That sounds great-hopefully, someday soon that is how this disease will be approached for everyone. I hate the guessing game of which chemo might work best for someone, and that we still have to rely on therapies that hurt healthy cells. This has been such a frustrating journey in part because there is no one way to attack this disease. Thank you so much for sharing the information and I’ll keep Lauren and you in my prayers.
TraceyJanuary 28, 2013 at 5:30 pm #68696pamelaParticipant
My daughter, Lauren just began taking part in a research study at U of M. The name of the study is Tumor Profiling through High-throughput Sequencing: Identification of molecular changes in cancer patients. The study is to offer mutational analysis of tumor samples for patients with cancer in hopes of identifying key genes important to cancer cells that could influence clinical decission making for managing cancer. Basically, this means they are looking for what chemo will work best on an individual’s tumors. They took blood, cheek swab, saliva, and did a liver biopsy. It takes about 4-6 weeks for results. She had it done last week. It is not guaranteed to work, but we feel it will be great if it does. So, hopefully there will be a way to give those tumors a swift kick!!! Just thought you might like to know. All the best to you and your Father.
-PamJanuary 28, 2013 at 4:58 am #7885tschildren7Member
Just wanted to share this piece of information…There is a clinical trial about to open at Wake Forest that is geared specifically toward cholangiocarcinoma! The agent is CP1-613, a novel chemotherapy agent that targets just the cancer cells. Has anyone heard of this drug? Everything I’ve read sounds promising; phrases like “strong anti-tumor activity” are being used to describe its effects.
My father is hanging in there; however, he was taken out of the clinical trial he was enrolled in at MUSC because his tumors grew more than 20%. We need a new plan…choice will be between a trial using ramucirumab with irinotecan and 5-FU (which sounds arduous; side effects of irinotecan sound tough) or the Wake Forest trial. Sure wish there was some way to know which would really give those tumors a swift kick…!
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