Hi Lisa,
The first chemo that John was on was Folfox for two cycles and then Avastin was added for ten more cycles. He had significant response so Folfox was discontinued and he only had Avastin every other week until his scans showed progression. He was put back on Folfox with Avastin but near the end of his sixth cycle had severe back pain. At the beginning of his seventh cycle, he started shaking with chills and they had to stop and kept putting heated blankets on him. They attributed this as an adverse reaction to the oxaliplatin. The side effects that John had were: sensitivity to cold, tingling in hands and feet, and fatigue. Since then, I have been told that the Avastin causes a lot of fatigue. Actually, we thought that he did very well with the Folfox until he had to quit. He was on this from April ’09 until the end of August ’10. Hope this helps, PeggyP