Not CC but Cholangiolocarcinoma (CLC). What the F is this?

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Viewing 15 posts - 1 through 15 (of 17 total)
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  • March 10, 2011 at 5:30 am #48417
    marions
    Moderator

    Hi Roslyn… as far as I know the procedure usually takes less than an hour with a general recovery from two to six hours. Some of our members reported little side effects and usually were up and about within a few days with some residual tiredness for about one to two weeks. The New Zealand Holiday is a perfect idea. Enjoy rest up and have good thoughts.
    All my best wishes,
    Marion

    March 10, 2011 at 4:17 am #48416
    charlea
    Spectator

    Thank you, Roslyn, for sharing this information. Maybe there will be someone out there desperate for information on this extremely rare form of liver cancer. All of this seems so incredibly complicated for the lay person to understand and I’m sure even some physicians find it over their heads. That’s why this site is so important to us all. It smooths the way to understanding what a formidable enemy this is and gives us the information and courage to fight and fight and fight until we can no longer.

    March 10, 2011 at 4:05 am #48415
    lainy
    Spectator

    Roslyn, good news about Bill being able to have this treatment done. A vacation sounds like the very best perscription that he could have. Please let us know when Bill is to go in for the procedure and in the eantime have a most wonderful vacation!

    March 10, 2011 at 3:35 am #48414
    duchess
    Member

    Hi,
    Just wanted to share some promising news with you. My husband, Bill, had his exploratory procedure yesterday & based on the areas that the dye reached when inserted into the Hepatic Artery, the doctors will be inserting radioactive spheres in early April. This will make him really sick &, unfortunately, the radioactive spheres do not discriminate- they damage all the bad & good cells they touch. Hopefully, they will touch the tumour cells mostly. Anyway, good liver cells can regrow. Hopefully the damned cancer cells wont. Wish him luck. I’m taking Bill on a holiday to New Zealand in two weeks time -he needs a break from medication, work & the normal routine. But I will be sure to let you know how the next stage of his treatment goes.
    Best wishes to everyone out there who uses this site.
    Regards
    Roslyn

    March 4, 2011 at 6:56 am #48413
    marions
    Moderator

    Roslyn….thank you for sharing this valuable information and yes, it most likely will help someone else diagnosed with this rare disease of cholangiolocarcinoma. Good luck on the upcoming procedure. Fingers are crossed for everything to turn out the best it can be.
    All my best wishes,
    Marion

    March 4, 2011 at 6:13 am #48412
    duchess
    Member

    Hi everyone,
    I have continued my search for info on Cholangiolocarcinoma (CLC).
    It seems that CLC has the clinical features resembling HCC but the morphologic features resembling CCC. It is suggested that CLC cells might be derived from Hering’s canal or stem cells which have the intermediate features between heptocytes & bile duct epithelium. Bill’s CLC’s are whitish in colour & solid, not encapsulated & resemble CCC.
    Hope this info helps some one else too.
    I will continue to look for info on this strange disease & share my findings with anyone who cares to read my blogs. Knowledge is strength.
    bill goes into the Wesley Hospital, in Brisbane, for his exploratory procedure. If successful, he will later have radioactive spheres injected into the Hepatic artery. Hope you are travelling well.
    regards
    Roslyn

    March 2, 2011 at 2:05 am #48411
    duchess
    Member

    Thank You, Marion. I would appreciate that very much.
    Regards
    Roslyn( Duchess)

    February 28, 2011 at 6:52 am #48410
    marions
    Moderator

    Roselyn……Good luck with the upcoming procedure. Roselyn, when attending the American Society of Clinical Oncology in Chicago in June I will make sure to search for some information regarding this apparently rarer than rare cancers. Hopefully, something will be presented.
    All my best wishes,
    Marion

    February 28, 2011 at 3:18 am #48409
    lainy
    Spectator

    ROSLYN, may I suggest rather than NC Institute you look up Mayo Clinic Rochester MN and try cholangiocarcinoma. What I like about your ONC is that he is willing to keep tring different things and that is so important. Much good luck on the trials and I know you will let us know how it goes. Wishing it goes very well!

    February 28, 2011 at 2:57 am #48408
    duchess
    Member

    Hi Guys,
    Thanks for trying to help with info. Bill’s onc says to get info from National Cancer Institute(USA) under liver cancer. There is some info about other cases there-very difficult for non-medical people to understand.

    Bill has next to meet with a radiologist whowill give him a trial by inserting dye into the hepatic artery (going in through the groin & up- similiar to inserting a stent in the heart). If the dye goes to the tumours, he will on another day insert radioactive spheres into the Hepatic artery, using the same method.This should make Bill feel very unwell. Oncologist is hopeful that this may shrink the tumours but, of course, no certainty. If no help then the onc will try something else. One step at a time.

    It helps to come onto rthis site & share with others whose experiences are similar. So Thanks everyone. Hope your journeys are proceeding postively.
    Regards
    Roslyn

    February 28, 2011 at 2:44 am #48407
    duchess
    Member

    The Oncologist spells this disease- CholangioLOcarcinoma. like CC but with a added “LO”.
    regards
    Roslyn

    February 26, 2011 at 3:34 am #48406
    magic
    Spectator

    Roslyn,I am not familiar with this type of cancer.It seems ultra rare.
    It seems to me that your oncologist is doing his best to research it and obtain the information from where he can.As you like him and have a good rapport I think you should stick with him.If you were coming down to Sydney anyway you could get another opinion but maybe not travel down specially.
    It does explain the different choice of chemo,I did wonder about that.
    good luck Janet

    February 25, 2011 at 6:43 pm #48405
    gavin
    Moderator

    Hi Rosyln,

    When the onc talked of CLC, did they say it was Cholangiocellular Carcinoma? If so I found these links on google that may be of interest to you.

    http://books.google.co.uk/books?id=R0FbhLsWHBEC&pg=PA1130&lpg=PA1130&dq=clc+cancer+bile+hepatic&source=bl&ots=yGnsfE_k3O&sig=i0bDGttoxO-FoIeJBSZF2KBQ93g&hl=en&ei=4PZnTfPaIo20hAfY07XyDg&sa=X&oi=book_result&ct=result&resnum=1&ved=0CBoQ6AEwAA#v=onepage&q=clc%20cancer%20bile%20hepatic&f=false

    And

    http://www.google.co.uk/#sclient=psy&hl=en&safe=off&q=cholangiocellular+carcinoma&aq=1&aqi=g2g-v2g-o1&aql=&oq=&pbx=1&fp=3aab4f875d701388

    I hope that some of them will be of use to you.

    Best wishes,

    Gavin

    February 25, 2011 at 12:24 pm #48404
    andie
    Spectator

    Hi The only info on the web I could find was this study information

    We clinicopathologically studied 6 resected cases of cholangiolocarcinoma (CLC) including 2 referred cases from other hospitals. The frequency of CLC was 0.56% of the 708 consecutively resected cases of primary liver cancer and the mean age of CLC cases was 66 years. Three of the 6 cases (50%) were hepatitis C virus antibody (HCVab) positive, one (17%) was hepatitis B virus surface antigen (HBsAg) positive, and 2 (33%) were negative to both HCVAb and HBsAg. Serum levels of alpha-fetoprotein were slightly elavated only in 1 case. Clinically, 4 cases were diagnosed as hepatocellular carcinoma (HCC) and 2 cases as cholangiocellular carcinoma (CCC). Grossly, CLCs were whitish in color and solid, not encapsulated, and resembled CCC. Histologically, the tumor cells had eosinophilic cytoplasm with ovoid nuclei, and mild atypia. The tumor proliferated in an anastomosing pattern of Hering’s canal-like small glands with an abundant fibrous stroma. Four of the 6 tumors (83%) consisted of only CLC and other 2 tumors contained CCC-like area and HCC-like area in a part of the nodules, respectively. Immunohistochemically, all tumors were positive to cytokeratin (CK) 7. CK8 were also positive in all of 6 cases. These results revealed that CLC had the clinical features resembling HCC but the morphologic features resembling CCC. It is suggested that CLC cells might be derived from Hering’s canal or stem cells which have the intermediate features between hepatocytes and bile duct epithelium

    Sorry it is long but it may help you understand the difference, or someone may be able to describe it better

    Best wishes

    Andrea

    February 25, 2011 at 6:43 am #48403
    nancy246
    Spectator

    Hi Roslyn, I was able to find a little information on the web. I would ask your oncologist for some written information. Has the oncologist suggested something as the next course of action? Keep asking questions! Hugs. Nancy

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